The bile acid receptor, TGR5, regulates basal and cholinergic‐induced secretory responses in rat colon

Bile acids (BA) are becoming increasingly appreciated as enteric hormones that regulate many aspects of intestinal physiology. The BA receptor, TGR5, has been recently shown to be expressed on enteric nerves and enterochromaffin cells (ECs), where its activation regulates small intestinal and coloni...

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Published inNeurogastroenterology and motility Vol. 25; no. 8; pp. 708 - 711
Main Authors Ward, J. B. J., Mroz, M. S., Keely, S. J.
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.08.2013
Subjects
Animals
Bile
bile acid
Bile Acids and Salts - physiology
chloride secretion
Cholic Acids - pharmacology
Cholinergic Neurons - drug effects
Cholinergic Neurons - physiology
Colon
Colon - drug effects
Colon - physiology
Colon - secretion
Epithelial Cells - drug effects
Epithelial Cells - physiology
Epithelial Cells - secretion
epithelial transport
Organ Culture Techniques
Rats
Receptors, G-Protein-Coupled - agonists
Receptors, G-Protein-Coupled - physiology
Rodents
TGR5
TGR5
chloride secretion
epithelial transport
bile acid
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Summary:Bile acids (BA) are becoming increasingly appreciated as enteric hormones that regulate many aspects of intestinal physiology. The BA receptor, TGR5, has been recently shown to be expressed on enteric nerves and enterochromaffin cells (ECs), where its activation regulates small intestinal and colonic motility. Here, we show that TGR5 is also expressed on colonic epithelial cells and that its activation decreases basal secretory tone and inhibits cholinergic‐induced secretory responses. Our data demonstrate a new role for TGR5 in regulating colonic fluid and electrolyte transport and suggest that the receptor represents a good therapeutic target for intestinal transport disorders.
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ISSN:1350-1925
1365-2982
DOI:10.1111/nmo.12148