p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A1 Implications for Alzheimer's disease

The paired helical filament (PHF), which comprises the major fibrous element of the neurofibrillary tangle of Alzheimer's disease, is composed of abnormally phosphorylated microtubule‐associated protein tau. Here we show that p42 MAP kinase phosphorylates recombinant tau and converts it to a fo...

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Bibliographic Details
Published inFEBS letters Vol. 312; no. 1; pp. 95 - 99
Main Authors Goedert, Michel, Cohen, E.Suzanne, Jakes, Ross, Cohen, Philip
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier 02.11.1992
Subjects
Alzheimer's disease
Biological and medical sciences
Brain - metabolism
Calcium - pharmacology
Calcium-Calmodulin-Dependent Protein Kinases
Cloning, Molecular
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Electrophoresis, Polyacrylamide Gel
Ethers, Cyclic - pharmacology
Humans
Kinetics
Magnesium - pharmacology
Medical sciences
Microtubule-associated protein tau
Mitogen-activated protein kinase
Neurology
Okadaic Acid
Phosphoprotein Phosphatases - antagonists & inhibitors
Phosphoprotein Phosphatases - metabolism
Phosphorylation
Protein Kinases - metabolism
Protein Phosphatase 2
Protein phosphatase 2A
Recombinant Proteins - metabolism
tau Proteins - isolation & purification
tau Proteins - metabolism
Nervous system diseases
Phosphorylation
Pathophysiology
Enzyme
Alzheimer disease
Paired helical filament
Phosphoprotein phosphatase
Dephosphorylation
Neurofibrillary tangle
In vitro
Vertebrata
Mammalia
Enzymatic activity
Degenerative disease
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Summary:The paired helical filament (PHF), which comprises the major fibrous element of the neurofibrillary tangle of Alzheimer's disease, is composed of abnormally phosphorylated microtubule‐associated protein tau. Here we show that p42 MAP kinase phosphorylates recombinant tau and converts it to a form which is similar to PHF tau. Of the major serine/threonine protein phosphatases found in mammalian tissues only protein phosphatase 2A (PP2A) could dephosphorylate tau phosphorylated in this manner, with PP2A1 being the most effective form of the enzyme.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(92)81418-L