THE MEAN CIRCULATORY PRESSURE, REPRODUCIBILITY OF ITS MEASUREMENTS AND THE EFFECT OF PHENYLEPHRINE WITH A NOTE ON THE EFFECT OF PENTOBARBITAL

With 7 repeated measurements of the mean circulatory pressure (MCP) over a course of 35 minutes in one and the same dog, and also with paired measurements of MCP 10 minutes apart in 6 other dogs, the MCP was shown to be stable and reproducible in anesthetized, open-chest and vagus-intact dogs. Admin...

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Published inJAPANESE CIRCULATION JOURNAL Vol. 39; no. 4; pp. 403 - 409
Main Authors HIRAKAWA, SENRI, ITO, HIROYASU, KONDO, YASUSHI, WATANABE, IKUO, HIEI, KUNIHIKO, BANNO, SHOHACHI, HAYASE, SHOJI
Format Journal Article
LanguageEnglish
Published Japan The Japanese Circulation Society 01.01.1975
Subjects
Animals
Aorta - physiology
Atrial Function
Blood Pressure - drug effects
Cardiac Output - drug effects
Dogs
Manometry
Pentobarbital - pharmacology
Phenylephrine - pharmacology
Vascular Resistance - drug effects
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Summary:With 7 repeated measurements of the mean circulatory pressure (MCP) over a course of 35 minutes in one and the same dog, and also with paired measurements of MCP 10 minutes apart in 6 other dogs, the MCP was shown to be stable and reproducible in anesthetized, open-chest and vagus-intact dogs. Administered to 7 dogs with initial mean arterial blood pressure as low as 64mmHg in dose of 20μg/kg intravenously, phenylephrine nearly doubled the mean arterial blood pressure, total peripheral resistance and the MCP, indicating a marked vasoconstrictor effect on the resistance and capacitance blood vessels of the systemic circulation. The effect was transient and there were signs of tachyphylaxis. Influence of a cardiotoxic dose of pentobarbital on the peripheral circulation was discussed.
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ISSN:0047-1828
1347-4839
DOI:10.1253/jcj.39.403