EFFECT OF NOCARDIA AND MYCOBACTERIUM CELL-WALL SKELETONS ON AUTOCHTHONOUS TUMOR GRAFTS

Cell-wall skeleton of Nocardia rubra and of Mycobcterium bovis BCG in the oilattached form, when injected mixed with autografts of spontaneous mammary adenocarcinoma or of methylcholanthrene-induced sarcoma of mice, suppresses the growth of tumor autografts to a demonstrable extent. The BCG whole ce...

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Published inGANN Japanese Journal of Cancer Research Vol. 66; no. 4; pp. 433 - 435
Main Authors TOKUZEN, Reiko, OKABE, Midori, NAKAHARA, Waro, AZUMA, Ichiro, YAMAMURA, Yuichi
Format Journal Article
LanguageEnglish
Published The Japanese Cancer Association 01.01.1975
Subjects
Autograft
Cell-wall skeleton
Mycobacterium
Norcardia
Tumor immunotherapy
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Summary:Cell-wall skeleton of Nocardia rubra and of Mycobcterium bovis BCG in the oilattached form, when injected mixed with autografts of spontaneous mammary adenocarcinoma or of methylcholanthrene-induced sarcoma of mice, suppresses the growth of tumor autografts to a demonstrable extent. The BCG whole cell wall showed no effect. The local destruction of tumor autografts did not induce recognizable systemic immunity to the respective tumors. These findings are commented upon from immunological and chemical points of view.
ISSN:0016-450X
DOI:10.20772/cancersci1959.66.4_433