生活環境における銀曝露とその健康影響
「1. はじめに」銀と人類との係わりは紀元前3000年前に遡るが, 現在に至るまで, 装飾品・食器などの極めて身近なツールとして利用されてきているほか, 電気および熱伝導率また可視光線の反射率特性を利用したパソコンの半導体やテレビ, 携帯電話の液晶画面の素材など, 銀の用途は多岐に渡る. その一方で, 近年多用されている銀ナノ粒子は, 健康リスクが懸念される材料としても国際的に注目を浴びるようになった. 実際に産業で用いられている銀が, 環境中にどのような化学形態および形状で放出され, あるいは存在し, ヒトの健康に影響を与えているのかについては不明な点が多い. ここでは, これまでの銀や銀ナ...
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| Published in | 日本衛生学雑誌 Vol. 67; no. 3; pp. 383 - 389 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人日本衛生学会
2012
日本衛生学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-5082 1882-6482 |
| DOI | 10.1265/jjh.67.383 |
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| Abstract | 「1. はじめに」銀と人類との係わりは紀元前3000年前に遡るが, 現在に至るまで, 装飾品・食器などの極めて身近なツールとして利用されてきているほか, 電気および熱伝導率また可視光線の反射率特性を利用したパソコンの半導体やテレビ, 携帯電話の液晶画面の素材など, 銀の用途は多岐に渡る. その一方で, 近年多用されている銀ナノ粒子は, 健康リスクが懸念される材料としても国際的に注目を浴びるようになった. 実際に産業で用いられている銀が, 環境中にどのような化学形態および形状で放出され, あるいは存在し, ヒトの健康に影響を与えているのかについては不明な点が多い. ここでは, これまでの銀や銀ナノ粒子に関する毒性学的知見を紹介しながら, 筆者らが行っている銀イオンと銀ナノ粒子を曝露した細胞における研究を紹介する. 「2. ナノリスクが懸念される材料としての銀の規制」ナノマテリアルは我々の生活に大きな利益をもたらすことが期待されているが, 環境リスクという観点からは不明の点が多く, 近年各国で使用の規制をする動きが出ている. |
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| AbstractList | 「1. はじめに」銀と人類との係わりは紀元前3000年前に遡るが, 現在に至るまで, 装飾品・食器などの極めて身近なツールとして利用されてきているほか, 電気および熱伝導率また可視光線の反射率特性を利用したパソコンの半導体やテレビ, 携帯電話の液晶画面の素材など, 銀の用途は多岐に渡る. その一方で, 近年多用されている銀ナノ粒子は, 健康リスクが懸念される材料としても国際的に注目を浴びるようになった. 実際に産業で用いられている銀が, 環境中にどのような化学形態および形状で放出され, あるいは存在し, ヒトの健康に影響を与えているのかについては不明な点が多い. ここでは, これまでの銀や銀ナノ粒子に関する毒性学的知見を紹介しながら, 筆者らが行っている銀イオンと銀ナノ粒子を曝露した細胞における研究を紹介する. 「2. ナノリスクが懸念される材料としての銀の規制」ナノマテリアルは我々の生活に大きな利益をもたらすことが期待されているが, 環境リスクという観点からは不明の点が多く, 近年各国で使用の規制をする動きが出ている. |
| Author | 宮山, 貴光 荒井, 裕太 平野, 靖史郎 |
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(12) Miyayama T, Ishizuka Y, Iijima T, Hiraoka D, Ogra Y. Roles of copper chaperone for superoxide dismutase 1 and metallothionein in copper homeostasis. Metallomics. 2011; 3:693–701. (1) Nageli KV. On the oligodynamic phenomenon in living cells. Denkschriften der Schweizerischen Naturforschenden Gesellschaft. 1893;33:174–182. (2) Landsdown AB, Williams A. Bacterial resistance to silver in wound care and medical devices. J Wound Care. 2007; 16:15–19. (40) Domaille DW, Que EL, Chang CJ. Synthetic fluorescent sensors for studying the cell biology of metals. Nat Chem Biol. 2008;4:168–175. (50) Asharani PV, Hande MP, Valiyaveettil S. Anti-proliferative activity of silver nanoparticles. BMC Cell Biol. 2009;10:65. (10) Kagi JH, Kojima Y. Chemistry and biochemistry of metallothionein. Experientia Suppl. 1987;52:25–61. (21) Dempsey EW, Wislocki GB. The use of silver nitrate as a vital stain, and its distribution in several mammalian tissues as studied with the electron microscope. J Biophys Biochem Cytol. 1955;1:111–118. (38) Hiura TS, Li N, Kaplan R, Horwitz M, Seagrave JC, Nel AE. The role of a mitochondrial pathway in the induction of apoptosis by chemicals extracted from diesel exhaust particles. J Immunol. 2000;165:2703–2711. (17) Rungby J, Hultman P, Ellermann-Erikson S. Silver affects viability and structure of cultured mouse peritoneal macrophages and peroxidative capacity of whole mouse liver. Arch Toxicol. 1987;59:408–412. (46) Sung JH, Ji JH, Park JD, Yoon JU, Kim DS, Jeon KS, Song MY, Jeong J, Han BS, Han JH, Chung YH, Chang HK, Lee JH, Cho MH, Kelman BJ, Yu IJ. Subchronic inhalation toxicity of silver nanoparticles. Toxicol Sci. 2009;108: 452–461. (19) Atiyeh BS, Costagliola M, Hayek SN, Dibo SA. Effect of silver on burn wound infection control and healing: Review of the literature. Burns. 2007;33:139–148. (25) Fung MC, Weintraub M, Bowen DL. Colloidal silver proteins marketed as health supplements. JAMA. 1995;274: 1196–1197. (26) Bleehen SS, Gould DJ, Harrington CI, Durrant TE, Slater DN, Underwood JC. Occupational argyria; light and electron microscopic studies and X-ray microanalysis. Br J Dermatol. 1981;104:19–26. (37) Upadhyay D, Panduri V, Ghio A, Kamp DW. Particulate matter induces alveolar epithelial cell DNA damage and apoptosis: role of free radicals and the mitochondria. Am J Respir Cell Mol Biol. 2003;29:180–187. (48) Lee YS, Kim DW, Lee YH, Oh JH, Yoon S, Choi MS, Lee SK, Kim JW, Lee K, Song CW. Silver nanoparticles induce apoptosis and G2/M arrest via PKCzeta-dependent signaling in A549 lung cells. Arch Toxicol. 2011;85:1529–1540. (36) Hussain SM, Hess KL, Gearhart JM, Geiss KT, Schlager JJ. In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol In Vitro. 2005;19:975–983. (49) AshaRani PV, Low Kah Mun G, Hande MP, Valiyaveettil S. Cytotoxicity and genotoxicity of silver nanoparticles in human cells. ACS Nano. 2009;3:279–290. (29) Hostynek JJ, Hinz RS, Lorence CR, Price M, Guy RH. Metals and the skin. Crit Rev Toxicol. 1993;23:171–235. (28) Lansdown AB. Physiological and toxicological changes in the skin resulting from the action and interaction of metal ions. Crit Rev Toxicol. 1995;25:397–462. (47) Trickler WJ, Lantz SM, Murdock RC, Schrand AM, Robinson BL, Newport GD, Schlager JJ, Oldenburg SJ, Paule MG, Slikker W Jr, Hussain SM, Ali SF. Silver nanoparticle induced blood-brain barrier inflammation and increased permeability in primary rat brain microvessel endothelial cells. Toxicol Sci. 2010;118:160–170. (16) Hidalgo E, Domínguez C. Study of cytotoxicity mechanisms of silver nitrate in human dermal fibroblasts. Toxicol Lett. 1998;98:169–179. (22) Drasch G, Gath HJ, Heissler E, Schupp I, Roider G. Silver concentrations in human tissues. their dependence on dental amalgam and other factors. J Trace Elem Med Biol. 1995;9: 82–87. (15) Miyayama T, Ogra Y, Osima Y, Suzuki KT. Narrow-bore HPLC-ICP-MS for speciation of copper in mutant mouse neonates bearing a defect in Cu metabolism. Anal Bioanal Chem. 2008;390:1799–1803. (11) Chan HM, Cherian MG, Bremner I. Quantification of metallothionein isoforms using an enzyme-linked immunosorbent assay (ELISA) with two specific antisera. Toxicol Appl Pharmacol. 1992;116:267–270. (33) Teodoro JS, Simoes AM, Duarte FV, Rolo AP, Murdoch RC, Hussain SM, Palmeira CM. Assessment of the toxicity of silver nanoparticles in vitro: a mitochondrial perspective. Toxicol In Vitro. 2011;25:664–670. (23) Viala A, Gilles G, Sauve JM, Alibert JP. [Influence of dental amalgams on the concentration of mercury and silver in biological fluids and hair (author’s transl)]. Toxicol Eur Res. 1979;2:47–53. (9) Kabzinski AK. The determination of environmental and industrial exposure to heavy metals based on the quantitative isolation of metallothionein from human fluids, with application of covalent affinity chromatography with thiol-disulphide interchange gel as a solid-phase extraction support. Talanta. 1998;46:335–346. (27) Takenaka S, Karg E, Roth C, Schulz H, Ziesenis A, Heinzmann U, Schramel P, Heyder J. Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats. Environ Health Perspect. 2001;109 Suppl 4:547–551. (30) Drake PL, Hazelwood KJ. Exposure-related health effects of silver and silver compounds: a review. Ann Occup Hyg. 2005;49:575–585. (13) Miyayama T, Hiraoka D, Kawaji F, Nakamura E, Suzuki N, Ogra Y. Roles of COMM-domain-containing 1 in stability and recruitment of the copper-transporting ATPase in a mouse hepatoma cell line. Biochem J. 2010;429:53–61. (8) Burrell RE. A scientific perspective on the use of topical silver preparations. Ostomy Wound Manage. 2003;49:19–24. (31) Foldbjerg R, Olesen P, Hougaard M, Dang DA, Hoffmann HJ, Autrup H. PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytes. Toxicol Lett. 2009;190:156–162. (34) Greulich C, Diendorf J, Simon T, Eggeler G, Epple M, Köller M. Uptake and intracellular distribution of silver nanoparticles in human mesenchymal stem cells. Acta Biomaterialia. 2011;7:347–354. (20) Lansdown AB. Silver in health care: antimicrobial effects and safety in use. Curr Probl Dermatol. 2006;33:17–34. (18) Baldi C, Minoia C, Di Nucci A, Capodaglio E, Manzo L. Effects of silver in isolated rat hepatocytes. Toxicol Lett. 1988;41:261–268. (51) Foldbjerg R, Dang DA, Autrup H. Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549. Arch Toxicol. 2011;85:743–750. (4) Carsin H, Wassermann D, Pannier M, Dumas R, Bohbot S. A silver sulphadiazine-impregnated lipidocolloid wound dressing to treat second-degree burns. J Wound Care. 2004; 13:145–148. (14) Miyayama T, Suzuki KT, Ogra Y. Copper accumulation and compartmentalization in mouse fibroblast lacking metallothionein and copper chaperone, Atox1. Toxicol Appl Pharmacol. 2009;237:205–213. (24) Lansdown AB. A pharmacological and toxicological profile of silver as an antimicrobial agent in medical devices. Adv Pharmacol Sci. 2010;2010:910686. |
| References_xml | – reference: (37) Upadhyay D, Panduri V, Ghio A, Kamp DW. Particulate matter induces alveolar epithelial cell DNA damage and apoptosis: role of free radicals and the mitochondria. Am J Respir Cell Mol Biol. 2003;29:180–187. – reference: (23) Viala A, Gilles G, Sauve JM, Alibert JP. [Influence of dental amalgams on the concentration of mercury and silver in biological fluids and hair (author’s transl)]. Toxicol Eur Res. 1979;2:47–53. – reference: (31) Foldbjerg R, Olesen P, Hougaard M, Dang DA, Hoffmann HJ, Autrup H. PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytes. Toxicol Lett. 2009;190:156–162. – reference: (24) Lansdown AB. A pharmacological and toxicological profile of silver as an antimicrobial agent in medical devices. Adv Pharmacol Sci. 2010;2010:910686. – reference: (12) Miyayama T, Ishizuka Y, Iijima T, Hiraoka D, Ogra Y. Roles of copper chaperone for superoxide dismutase 1 and metallothionein in copper homeostasis. Metallomics. 2011; 3:693–701. – reference: (41) Lansdown AB. Metallothioneins: potential therapeutic aids for wound healing in the skin. Wound Repair Regen. 2002; 10:130–132. – reference: (7) Wright JB, Lam K, Hansen D, Burrell RE. Efficacy of topical silver against fungal burn wound pathogens. Am J Infect Control. 1999;27:344–350. – reference: (27) Takenaka S, Karg E, Roth C, Schulz H, Ziesenis A, Heinzmann U, Schramel P, Heyder J. Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats. Environ Health Perspect. 2001;109 Suppl 4:547–551. – reference: (10) Kagi JH, Kojima Y. Chemistry and biochemistry of metallothionein. Experientia Suppl. 1987;52:25–61. – reference: (51) Foldbjerg R, Dang DA, Autrup H. Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549. Arch Toxicol. 2011;85:743–750. – reference: (14) Miyayama T, Suzuki KT, Ogra Y. Copper accumulation and compartmentalization in mouse fibroblast lacking metallothionein and copper chaperone, Atox1. Toxicol Appl Pharmacol. 2009;237:205–213. – reference: (4) Carsin H, Wassermann D, Pannier M, Dumas R, Bohbot S. A silver sulphadiazine-impregnated lipidocolloid wound dressing to treat second-degree burns. J Wound Care. 2004; 13:145–148. – reference: (13) Miyayama T, Hiraoka D, Kawaji F, Nakamura E, Suzuki N, Ogra Y. Roles of COMM-domain-containing 1 in stability and recruitment of the copper-transporting ATPase in a mouse hepatoma cell line. Biochem J. 2010;429:53–61. – reference: (28) Lansdown AB. Physiological and toxicological changes in the skin resulting from the action and interaction of metal ions. Crit Rev Toxicol. 1995;25:397–462. – reference: (44) Li PW, Kuo TH, Chang JH, Yeh JM, Chan WH. Induction of cytotoxicity and apoptosis in mouse blastocysts by silver nanoparticles. Toxicol Lett. 2010;197:82–87. – reference: (21) Dempsey EW, Wislocki GB. The use of silver nitrate as a vital stain, and its distribution in several mammalian tissues as studied with the electron microscope. J Biophys Biochem Cytol. 1955;1:111–118. – reference: (29) Hostynek JJ, Hinz RS, Lorence CR, Price M, Guy RH. Metals and the skin. Crit Rev Toxicol. 1993;23:171–235. – reference: (47) Trickler WJ, Lantz SM, Murdock RC, Schrand AM, Robinson BL, Newport GD, Schlager JJ, Oldenburg SJ, Paule MG, Slikker W Jr, Hussain SM, Ali SF. Silver nanoparticle induced blood-brain barrier inflammation and increased permeability in primary rat brain microvessel endothelial cells. Toxicol Sci. 2010;118:160–170. – reference: (5) Carneiro PM, Rwanyuma LR, Mkony CA. A comparison of topical Phenytoin with Silverex in the treatment of superficial dermal burn wounds. Cent Afr J Med. 2002;48:105–108. – reference: (17) Rungby J, Hultman P, Ellermann-Erikson S. Silver affects viability and structure of cultured mouse peritoneal macrophages and peroxidative capacity of whole mouse liver. Arch Toxicol. 1987;59:408–412. – reference: (2) Landsdown AB, Williams A. Bacterial resistance to silver in wound care and medical devices. J Wound Care. 2007; 16:15–19. – reference: (32) Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, Wang M, Oberley T, Froines J, Nel A. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect. 2003;111:455–460. – reference: (43) Braydich-Stolle L, Hussain S, Schlager JJ, Hofmann MC. In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol Sci. 2005;88:412–419. – reference: (25) Fung MC, Weintraub M, Bowen DL. Colloidal silver proteins marketed as health supplements. JAMA. 1995;274: 1196–1197. – reference: (48) Lee YS, Kim DW, Lee YH, Oh JH, Yoon S, Choi MS, Lee SK, Kim JW, Lee K, Song CW. Silver nanoparticles induce apoptosis and G2/M arrest via PKCzeta-dependent signaling in A549 lung cells. Arch Toxicol. 2011;85:1529–1540. – reference: (1) Nageli KV. On the oligodynamic phenomenon in living cells. Denkschriften der Schweizerischen Naturforschenden Gesellschaft. 1893;33:174–182. – reference: (33) Teodoro JS, Simoes AM, Duarte FV, Rolo AP, Murdoch RC, Hussain SM, Palmeira CM. Assessment of the toxicity of silver nanoparticles in vitro: a mitochondrial perspective. Toxicol In Vitro. 2011;25:664–670. – reference: (26) Bleehen SS, Gould DJ, Harrington CI, Durrant TE, Slater DN, Underwood JC. Occupational argyria; light and electron microscopic studies and X-ray microanalysis. Br J Dermatol. 1981;104:19–26. – reference: (36) Hussain SM, Hess KL, Gearhart JM, Geiss KT, Schlager JJ. In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol In Vitro. 2005;19:975–983. – reference: (6) Monafo WW, Freedman B. Topical therapy for burns. Surg Clin North Am. 1987;67:133–145. – reference: (46) Sung JH, Ji JH, Park JD, Yoon JU, Kim DS, Jeon KS, Song MY, Jeong J, Han BS, Han JH, Chung YH, Chang HK, Lee JH, Cho MH, Kelman BJ, Yu IJ. Subchronic inhalation toxicity of silver nanoparticles. Toxicol Sci. 2009;108: 452–461. – reference: (39) Hiura TS, Kaszubowski MP, Li N, Nel AE. Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages. J Immunol. 1999; 163:5582–5591. – reference: (15) Miyayama T, Ogra Y, Osima Y, Suzuki KT. Narrow-bore HPLC-ICP-MS for speciation of copper in mutant mouse neonates bearing a defect in Cu metabolism. Anal Bioanal Chem. 2008;390:1799–1803. – reference: (19) Atiyeh BS, Costagliola M, Hayek SN, Dibo SA. Effect of silver on burn wound infection control and healing: Review of the literature. Burns. 2007;33:139–148. – reference: (30) Drake PL, Hazelwood KJ. Exposure-related health effects of silver and silver compounds: a review. Ann Occup Hyg. 2005;49:575–585. – reference: (22) Drasch G, Gath HJ, Heissler E, Schupp I, Roider G. Silver concentrations in human tissues. their dependence on dental amalgam and other factors. J Trace Elem Med Biol. 1995;9: 82–87. – reference: (35) Kim S, Choi JE, Choi J, Chung KH, Park K, Yi J, Ryu DY. Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cells. Toxicol In Vitro. 2009;23:1076–1084. – reference: (18) Baldi C, Minoia C, Di Nucci A, Capodaglio E, Manzo L. Effects of silver in isolated rat hepatocytes. Toxicol Lett. 1988;41:261–268. – reference: (20) Lansdown AB. Silver in health care: antimicrobial effects and safety in use. Curr Probl Dermatol. 2006;33:17–34. – reference: (3) Russell AD, Hugo WB. Antimicrobial activity and action of silver. Prog Med Chem. 1994;31:351–370. – reference: (8) Burrell RE. A scientific perspective on the use of topical silver preparations. Ostomy Wound Manage. 2003;49:19–24. – reference: (16) Hidalgo E, Domínguez C. 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| Snippet | 「1. はじめに」銀と人類との係わりは紀元前3000年前に遡るが, 現在に至るまで, 装飾品・食器などの極めて身近なツールとして利用されてきているほか, 電気および熱伝導率また可視光線の反射率特性を利用したパソコンの半導体やテレビ, 携帯電話の液晶画面の素材など, 銀の用途は多岐に渡る. その一方で,... |
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| SubjectTerms | ナノ粒子 メタロチオネイン 結膜銀症 銀 銀皮症 高速液体クロマトグラフィー–誘導結合プラズマ質量分析装置 |
| Title | 生活環境における銀曝露とその健康影響 |
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