Funalenone, a Novel Collagenase Inhibitor Produced by Aspergillus niger
Funalenone, a phenalene compound that inhibits type I collagenase (MMP-1), was isolated from mycelium of Aspergillus niger FO-5904 by solvent extaction, ODS column chromatography, Sephadex LH-20 column chromatography and reversed phase HPLC. Funalenone inhibited 50% of type I collagenase activity at...
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Published in | Journal of antibiotics Vol. 52; no. 12; pp. 1095 - 1100 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
TOKYO
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
01.12.1999
JAPAN ANTIBIOT RES ASSN Japan Antibiotics Research Association |
Subjects | |
Online Access | Get full text |
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Summary: | Funalenone, a phenalene compound that inhibits type I collagenase (MMP-1), was isolated from mycelium of Aspergillus niger FO-5904 by solvent extaction, ODS column chromatography, Sephadex LH-20 column chromatography and reversed phase HPLC. Funalenone inhibited 50% of type I collagenase activity at a concentration of 170 μM, but inhibited 18.3% and 38.7% against 72kDa and 92kDa type IV collagenase, respectively, at a concentration of 400 μM. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0021-8820 1881-1469 |
DOI: | 10.7164/antibiotics.52.1095 |