INDUCTION OF OVARIAN TUMOR IN RATS WITH N-BUTYLNITROSOUREA

Considerable number (8.2-10.7%) of ovarian tumors were produced in Sprague-Dawley adult rats treated with multiple oral or intramuscular administration of heavy doses of N-butylnitrosourea. Histologically the tumor was a clear-cell adenoma which reminded of embryonal testicular tissue. Electron micr...

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Published inGANN Japanese Journal of Cancer Research Vol. 66; no. 3; pp. 323 - 325
Main Authors FUKUNISHI, Ryo, WANG, Hao-Hui, YOSHIDA, Aichi, YOSHIDA, Hiroki, HIROTA, Norio, MORI, Hiroshi
Format Journal Article
LanguageEnglish
Published Japan The Japanese Cancer Association 01.06.1975
Subjects
Adenoma - chemically induced
Animals
Carcinogens
Female
N-Butylnitrosourea
Neoplasms, Experimental - chemically induced
Nitrosourea Compounds
Ovarian Neoplasms - chemically induced
Ovarian tumor
Rats
Sprague-Dawley rats
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Summary:Considerable number (8.2-10.7%) of ovarian tumors were produced in Sprague-Dawley adult rats treated with multiple oral or intramuscular administration of heavy doses of N-butylnitrosourea. Histologically the tumor was a clear-cell adenoma which reminded of embryonal testicular tissue. Electron micrograph revealed secretory function of the tumor cells. It was not possible to find histogenesis in the normal ovarian components.
ISSN:0016-450X
DOI:10.20772/cancersci1959.66.3_323