Effect of the traditional Japanese medicine Sairei-to on edema in mouse anti-GBM nephritis

• Published in: Journal of Traditional Medicines Vol. 21; no. 3; pp. 125 - 129
• Main Authors: TADA, Kinji, FUJITSUKA, Naoki, KOBAYASHI, Mii, MAKINO, Bunsho, ENDO, Yuichi, KASE, Yoshio, TAKEDA, Shuichi, ABURADA, Masaki
• Format: Journal Article
• Language: English; Japanese
• Published: Medical and Pharmaceutical Society for WAKAN-YAKU 2004; 和漢医薬学会
• Subjects: edema; extracellular fluid volume; nephritis; Sairei-to
• ISSN: 1880-1447; 1881-3747
• DOI: 10.11339/jtm.21.125

The purpose of this study is to clarify the effect of the traditional Japanese medicine Sairei-to (TJ-114) on edema in mice with anti-glomerular basement membrane (GBM) nephritis. Sairei-to (0.38-1.5 g/kg/day) and furosemide (50mg/kg/day) were orally administered consecutively for 4 days from day 6 after an anti-GBM serum injection. Plasma volume (PV) was determined with Evans blue dye and extracellular fluid volume (ECFV) was measured using a single-injection potassium bromide technique. In the nephritic control mice, proteinuria and hyponatreuria were induced and PV, ECFV and calculated interstitial fluid volume (ISFV) were increased. Sairei-to significantly decreased ECFV and ISFV in a dose-dependent manner, but did not change PV or urinary protein excretion. A similar result was observed in the furosemide-treated mice. These results suggest that the treatment with Sairei-to was useful against nephrotic edema.