INDUCTION OF ENZYME-ALTERED ISLANDS IN RAT LIVER BY A SINGLE TREATMENT WITH BENZO[a]PYRENE AFTER PARTIAL HEPATECTOMY

Hepatocarcinogenicity of benzo[a]pyrene was studied by intraperitoneal application of this compound to rats 24 hr after partial hepatectomy. Numerous enzyme-altered islands, similar to putative precancerous lesions induced by known hepatocarcinogens, developed by the 12th week.

Saved in:
Bibliographic Details
Published inGANN Japanese Journal of Cancer Research Vol. 70; no. 3; pp. 393 - 394
Main Authors HIRAKAWA, Tadashi, ISHIKAWA, Takatoshi, NEMOTO, Nobuo, TAKAYAMA, Shozo, KITAGAWA, Tomoyuki
Format Journal Article
LanguageEnglish
Published Japan The Japanese Cancer Association 01.01.1979
Subjects
Adenosine Triphosphatases - deficiency
Animals
Benzo[a]pyrene
Benzopyrenes - pharmacology
gamma-Glutamyltransferase - deficiency
Hepatectomy
Hepatocarcinogenesis
Liver - drug effects
Liver - enzymology
Liver - pathology
Liver Neoplasms - chemically induced
Liver Neoplasms - enzymology
Male
Partial hepatectomy
Phenobarbital - pharmacology
Precancerous change
Precancerous Conditions - chemically induced
Precancerous Conditions - enzymology
Rats
Online AccessGet full text

Cover

More Information
Summary:Hepatocarcinogenicity of benzo[a]pyrene was studied by intraperitoneal application of this compound to rats 24 hr after partial hepatectomy. Numerous enzyme-altered islands, similar to putative precancerous lesions induced by known hepatocarcinogens, developed by the 12th week.
ISSN:0016-450X
DOI:10.20772/cancersci1959.70.3_393