No evidence for an association between the 5‐hydroxytryptamine 5‐HT2a receptor gene and schizophrenia in Kuwaiti Arabs

• Published in: Psychiatry and clinical neurosciences Vol. 56; no. 4; pp. 465 - 467
• Main Authors: HAIDER, MOHAMMAD Z., ZAHID, MOHAMMAD A.
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Science Pty 01.08.2002; Blackwell Publishing
• Subjects: Adult; Adult and adolescent clinical studies; Aged; Arabs; Biological and medical sciences; Female; Humans; Kuwait; Male; Medical sciences; Middle Aged; Polymerase Chain Reaction; polymorphism; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin - genetics; Schizophrenia; Schizophrenia - genetics; serotonin; Tropical medicine; Kuwait; Asia; Social environment; Human; 5-HT2A serotonin receptor; Genetic marker; Schizophrenia; Genetic determinism; Ethnic group; Psychosis; Polymerase chain reaction; Arabic; Restriction fragment length polymorphism; Etiology; Cohort study; Genetics; Molecular biology; Polymorphism
• ISSN: 1323-1316; 1440-1819
• DOI: 10.1046/j.1440-1819.2002.01037.x

The prevalence of T102C polymorphism of the 5‐hydroxytryptamine 5‐HT2a receptor gene has been investigated using a polymerase chain reaction–restriction fragment length polymorphism (PCR‐RFLP) method in 80 Kuwaiti Arabs with schizophrenia and in 109 normal healthy controls with a similar ethnic background. There was no significant difference in the frequency of T102 polymorphism in the Kuwaiti cohort of schizophrenia patients and the controls (P = 0.23). The data from Kuwaiti Arabs (although our sample size is relatively small) support the findings from some other populations (Caucasians, Japanese), in which a lack of association has been found between T102C polymorphism and the onset of schizophrenia.