RIBONUCLEIC ACID METABOLISM IN LIVER NUCLEUS OF RAT FED CARCINOGENIC AMINOAZO DYES

Nuclear ribonucleic acids (RNA) of rat liver were fractionated into three different fractions; 0.1M phosphate, 1M sodium chloride, and residue fractions. RNA content and rate of orthophosphate [32P] incorporation into these fractions in vivo were followed during the course of feeding 4-dimethylamino...

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Published inGANN Japanese Journal of Cancer Research Vol. 55; no. 3; pp. 251 - 257
Main Author KONO, Masakiyo
Format Journal Article
LanguageEnglish
Published Japan The Japanese Cancer Association 01.01.1964
Subjects
Azo Compounds
Carcinogens
Cell Nucleus
Coloring Agents
Liver - cytology
Metabolism
p-Dimethylaminoazobenzene
Pharmacology
Phosphorus Isotopes
Proteins
Rats
RNA
RNA, Messenger
METABOLISM
DIMETHYLAMINOAZOBENZENE
PHARMACOLOGY
EXPERIMENTAL LAB STUDY
LIVER CYTOLOGY
RNA, MESSENGER
RATS
PHOSPHORUS ISOTOPES
AZO COMPOUNDS
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Summary:Nuclear ribonucleic acids (RNA) of rat liver were fractionated into three different fractions; 0.1M phosphate, 1M sodium chloride, and residue fractions. RNA content and rate of orthophosphate [32P] incorporation into these fractions in vivo were followed during the course of feeding 4-dimethylaminoazobenzene (DAB) for 3, 10, and 21 weeks. It was found that the incorporation of orthophosphate[32P] into RNA of residue fraction was stimulated approx. 2.8 times at 10 weeks. This was accompanied by a decrease in the amount of RNA. Little or no effect of DAB-feeding was observed for the other two fractions of RNA. Guanylic acid content of residue RNA decreased considerably by feeding 3'-methyl-aminoazobenzene (3'-methyl-DAB) for 8 weeks, whereas again no other fraction of RNA was altered in this respect. The significance of these findings was discussed briefly.
ISSN:0016-450X
DOI:10.20772/cancersci1959.55.3_251