Effect of Gelatin Hydrogel Containing BMP-2 on Bone Formation in Aged Rats

This study was designed to examine the effect of biodegradable gelatin hydrogel (Gel) containing bone morphogenetic protein-2 (BMP-2) on bone formation at palatal subperiosteal sites in 10-week-old (10w group) and 70-week-old (70w group) male Wistar rats. The experimental sites of both age groups we...

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Published inJournal of Oral Tissue Engineering Vol. 19; no. 1; pp. 10 - 14
Main Authors YAMAJI, Kozo, YOKOYAMA, Akihito, MATSUZAKI, Kumiko, OHARA, Naoko, SUGAYA, Tsutomu, YOSHIYAMA, Masahiro
Format Journal Article
LanguageEnglish
Japanese
Published Okayama Japanese Association of Regenerative Dentistry 01.01.2021
Japan Science and Technology Agency
Subjects
Age groups
aged rat
Aging
Biodegradability
Biodegradation
BMP-2
bone formation
Bone growth
Bone morphogenetic protein 2
Bone morphogenetic proteins
Gelatin
gelatin hydrogel
Hydrogels
Osteogenesis
Rodents
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Summary:This study was designed to examine the effect of biodegradable gelatin hydrogel (Gel) containing bone morphogenetic protein-2 (BMP-2) on bone formation at palatal subperiosteal sites in 10-week-old (10w group) and 70-week-old (70w group) male Wistar rats. The experimental sites of both age groups were divided into two implants: Gel containing BMP-2 (BMP site) and Gel only (Gel site).Four weeks after implantation, new bone formation was observed at every site and the thickness of new bone (TNB) of the BMP site was significantly greater than that of the Gel site of both age groups (p<0.05). The TNB of every site in the 10w group was significantly greater than that of the same experimental site in the 70w group (p<0.05).These results suggest that gelatin hydrogel containing BMP-2 induces new bone formation, even in senescent rats that otherwise have decreasing new bone formation because of aging.
ISSN:1348-9623
1880-0823
DOI:10.11223/jarde.19.10