ジアセチル曝露労働者に発症した閉塞性肺疾患
「I. はじめに」ジアセチル (化学式 C4H6O2) は別名2, 3-ブタンジオンといい, 2つのアセチル基がカルボニル基の炭素同士で結合したジケトンである. 酵母や乳酸菌などの微生物による発酵の際に生成する. 沸点は88℃で揮発性が高く, 強いバター臭があり, 食品香料として使用されている. 2000年に米国ミズーリ州のマイクロ波ポップコーン製造工場の労働者に閉塞性細気管支炎 (bronchiolitis obliterans) 様の疾患が多発していることが発覚した. マイクロ波ポップコーンとは, トウモロコシの実と食品香料などをマイクロ波加熱用袋に入れて密封したものであり, それを購入者...
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| Published in | 産業衛生学雑誌 Vol. 64; no. 4; pp. 211 - 220 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | Japanese |
| Published |
公益社団法人 日本産業衛生学会
20.07.2022
日本産業衛生学会 |
| Online Access | Get full text |
| ISSN | 1341-0725 1349-533X |
| DOI | 10.1539/sangyoeisei.2021-025-W |
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| Abstract | 「I. はじめに」ジアセチル (化学式 C4H6O2) は別名2, 3-ブタンジオンといい, 2つのアセチル基がカルボニル基の炭素同士で結合したジケトンである. 酵母や乳酸菌などの微生物による発酵の際に生成する. 沸点は88℃で揮発性が高く, 強いバター臭があり, 食品香料として使用されている. 2000年に米国ミズーリ州のマイクロ波ポップコーン製造工場の労働者に閉塞性細気管支炎 (bronchiolitis obliterans) 様の疾患が多発していることが発覚した. マイクロ波ポップコーンとは, トウモロコシの実と食品香料などをマイクロ波加熱用袋に入れて密封したものであり, それを購入者が電子レンジで加熱すれば, ポープコーンができる製品である. |
|---|---|
| AbstractList | 「I. はじめに」ジアセチル (化学式 C4H6O2) は別名2, 3-ブタンジオンといい, 2つのアセチル基がカルボニル基の炭素同士で結合したジケトンである. 酵母や乳酸菌などの微生物による発酵の際に生成する. 沸点は88℃で揮発性が高く, 強いバター臭があり, 食品香料として使用されている. 2000年に米国ミズーリ州のマイクロ波ポップコーン製造工場の労働者に閉塞性細気管支炎 (bronchiolitis obliterans) 様の疾患が多発していることが発覚した. マイクロ波ポップコーンとは, トウモロコシの実と食品香料などをマイクロ波加熱用袋に入れて密封したものであり, それを購入者が電子レンジで加熱すれば, ポープコーンができる製品である. |
| Author | 毛利, 一平 熊谷, 信二 |
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| DOI | 10.1539/sangyoeisei.2021-025-W |
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| References | 12) Kanwal, Kullman G, Piacitelli C, et al. Evaluation of flavorings-related lung disease risk at six microwave popcorn plants. J Occup Environ Med 2006;48:149–57. 2) American Conference of Governmental Industrial Hygienists (ACGIH). Diacetyl. In: Documentation of the Threshold Limit Values for chemical substances and physical agents and Biological Exposure Indices. Cincinnati: ACGIH, 2012. 23) Hubbs AF, Goldsmith WT, Kashon ML, et al. Respiratory toxicologic pathology of inhaled diacetyl in Sprague-Dawley rats. Toxicol Pathol 2008;36:330–44. 26) Gloede E, Cichocki JA, Baldino JB, Morris JB. A validated hybrid computational fluid dynamics-physiologically based pharmacokinetic model for respiratory tract vapor absorption in the human and rat and its application to inhalation dosimetry of diacetyl. Toxicol Sci 2011;123,231–246. 14) White KL, Heikkila K, Williams R, Levin L, Lockey JE, Rice C. Diacetyl exposures at four microwave popcorn plants. J Occup Environ Hyg 2010;7:185–93. 1) McKernan LT, Niemeier RT, Kreiss K, et al. Criteria for a recommended standard occupational exposure to diacetyl and 2,3-pentanedione. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health. [Online]. [cited 2021 April 4]; Available from: URL: https://www.cdc.gov/niosh/docs/2016-111/default.html 24) Morgan DL, Flake GP, Kirby PJ, Palmer SM. Respiratory toxicity of diacetyl in C57Bl/6 mice. Toxicol Sci 2008;103:169–80. 22) Hubbs AF, Battelli LA, Goldsmith WT, et al. Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring. Toxicol Appl Pharmacol 2002;185:128–35. 8) Cox-Ganser J, Ganser G, Saito R, et al. Correcting diacetyl concentrations from air samples collected with NIOSH Method 2557. J Occup Environ Hyg 2011;8:59–70. 25) Palmer SM, Flake GP, Kelly FL, et al. Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats. PLoS ONE 2011;6:e17644. 13) Lockey JE, Hilbert TJ, Levin LP. Airway obstruction related to diacetyl exposure at microwave popcorn production facilities. Eur Respir J 2009;34:63–71. 15) Centers for Disease Control and Prevention (CDC). Fixed obstructive lung disease among workers in the flavor-manufacturing industry – California, 2004–2007. Morb Mortal Wkly Rep 2007;56:389–93. [Online]. [cited 2021 April 4]; Available from: URL: https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5616a2.htm 17) Kreiss K, Fedan KB, Nasrullah M, et al. Longitudinal lung function declines among California flavoring manufacturing workers. Am J Ind Med 2012;55:657–68. 20) Martyny JW, Van Dyke MV, Arbuckle S, Towle M, Rose CS. Diacetyl exposures in the flavor manufacturing industry. J Occup Environ Hyg 2008;5:679–88. 7) Kreiss K, Gomaa A, Kullman GK, Fedan K, Simoes EJ, Enright PL. Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. N Engl J Med 2002;347:330–8. 11) Halldin CN, Suarthana E, Fedan KB, Lo YC, Turabelidze G, Kreiss K. Increased respiratory disease mortality at a microwave popcorn production facility with worker risk of bronchiolitis obliterans. PLoS One. 2013;8:e57935. 3) Centers for Disease Control and Prevention (CDC). Fixed obstructive lung disease in workers at a microwave popcorn factory—Missouri, 2000–2002. Morb Mortal Wkly Rep 2002;51:345–7. [Online]. [cited 2021 April 4]; Available from: URL: https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5116a2.htm 19) National Institute for Occupational Safety Health. 2010. Spirometry in the occupational setting: Spirometry longitudinal data analysis (SPIROLA) software. Atlanta, GA, USA: Centers for Disease Control and Prevention, NIOSH, Version 3.0, updated. November 2010. 27) Pierce JS, Abelmann A, Spicer LJ, Adams RE, Finley BL. Diacetyl and 2,3-pentanedione exposures associated with cigarette smoking: implications for risk assessment of food and flavoring workers. Crit Rev Toxicol 2014;44:420–35. 29) Deutsche Forschungsgemeinschaft (DFG). Diacetyl. In: List of MAK and BAT Values 2015. Bonn: DFG, 2015. 16) Kim TJ, Materna BL, Prudhomme JC, et al. Industry-wide medical surveillance of California flavor manufacturing workers: cross-sectional results. Am J Ind Med 2010;53:857–865. 18) Hnizdo E, Sircar K, Yan T, Harber P, Fleming J, Glindmeyer HW. 2007. Limits of longitudinal decline for the interpretation of annual changes in FEV1 in individuals. Occup Environ Med 64:701–7. 4) Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med 1999;159:179–87. 9) Kanwal R, Kullman G, Fedan KB, Kreiss K. Occupational lung disease risk and exposure to butter-flavoring chemicals after implementation of controls at a microwave popcorn plant. Publ Health Rep 2011;126:480–94. 10) Park RM, Gilbert SJ. Pulmonary impairment and risk assessment in a diacetyl-exposed population: microwave popcorn workers. J Occup Environ Med. 2018;60:496–506. 21) Fechter-Leggett ED, White SK, Fedan KB, Cox-Ganser MC, Cummings KJ. Burden of respiratory abnormalities in microwave popcorn and flavouring manufacturing workers. Occup Environ Med 2018;75:709–15. 28) Kreiss K. Recognizing occupational effects of diacetyl: What can we learn from this history? Toxicology 2017;388:48–54. 5) Akpinar-Elci M, Travis WD, Lynch DA. Bronchiolitis obliterans syndrome in popcorn production plant workers. Eur Respir J 2004;24:298–302. 6) Kullman G, Boylstein R, Jones W, Piacitelli C, Pendergrass S, Kreiss K. Characterization of respiratory exposures at a microwave popcorn plant with cases of bronchiolitis obliterans. J Occup Environ Hyg 2005;2:169–78. 30) 厚生労働省．ジアセチル（別名：2,3-ブタンジオン）による健康障害の防止対策及び労災保険制度の周知について（基安化発0607第6号 基補発0607第2号，基安化発0607第5号基補発0607第1号，令和3年6月7日），2021.［Online］. ［cited 2021 June 24］; Available from: URL: https://www.mhlw.go.jp/content/11300000/000789986.pdf |
| References_xml | – reference: 17) Kreiss K, Fedan KB, Nasrullah M, et al. Longitudinal lung function declines among California flavoring manufacturing workers. Am J Ind Med 2012;55:657–68. – reference: 29) Deutsche Forschungsgemeinschaft (DFG). Diacetyl. In: List of MAK and BAT Values 2015. Bonn: DFG, 2015. – reference: 10) Park RM, Gilbert SJ. Pulmonary impairment and risk assessment in a diacetyl-exposed population: microwave popcorn workers. J Occup Environ Med. 2018;60:496–506. – reference: 8) Cox-Ganser J, Ganser G, Saito R, et al. Correcting diacetyl concentrations from air samples collected with NIOSH Method 2557. J Occup Environ Hyg 2011;8:59–70. – reference: 14) White KL, Heikkila K, Williams R, Levin L, Lockey JE, Rice C. Diacetyl exposures at four microwave popcorn plants. J Occup Environ Hyg 2010;7:185–93. – reference: 2) American Conference of Governmental Industrial Hygienists (ACGIH). Diacetyl. In: Documentation of the Threshold Limit Values for chemical substances and physical agents and Biological Exposure Indices. Cincinnati: ACGIH, 2012. – reference: 28) Kreiss K. Recognizing occupational effects of diacetyl: What can we learn from this history? Toxicology 2017;388:48–54. – reference: 18) Hnizdo E, Sircar K, Yan T, Harber P, Fleming J, Glindmeyer HW. 2007. Limits of longitudinal decline for the interpretation of annual changes in FEV1 in individuals. Occup Environ Med 64:701–7. – reference: 22) Hubbs AF, Battelli LA, Goldsmith WT, et al. Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring. Toxicol Appl Pharmacol 2002;185:128–35. – reference: 11) Halldin CN, Suarthana E, Fedan KB, Lo YC, Turabelidze G, Kreiss K. Increased respiratory disease mortality at a microwave popcorn production facility with worker risk of bronchiolitis obliterans. PLoS One. 2013;8:e57935. – reference: 19) National Institute for Occupational Safety Health. 2010. Spirometry in the occupational setting: Spirometry longitudinal data analysis (SPIROLA) software. Atlanta, GA, USA: Centers for Disease Control and Prevention, NIOSH, Version 3.0, updated. November 2010. – reference: 26) Gloede E, Cichocki JA, Baldino JB, Morris JB. A validated hybrid computational fluid dynamics-physiologically based pharmacokinetic model for respiratory tract vapor absorption in the human and rat and its application to inhalation dosimetry of diacetyl. Toxicol Sci 2011;123,231–246. – reference: 30) 厚生労働省．ジアセチル（別名：2,3-ブタンジオン）による健康障害の防止対策及び労災保険制度の周知について（基安化発0607第6号 基補発0607第2号，基安化発0607第5号基補発0607第1号，令和3年6月7日），2021.［Online］. ［cited 2021 June 24］; Available from: URL: https://www.mhlw.go.jp/content/11300000/000789986.pdf – reference: 24) Morgan DL, Flake GP, Kirby PJ, Palmer SM. Respiratory toxicity of diacetyl in C57Bl/6 mice. Toxicol Sci 2008;103:169–80. – reference: 12) Kanwal, Kullman G, Piacitelli C, et al. Evaluation of flavorings-related lung disease risk at six microwave popcorn plants. J Occup Environ Med 2006;48:149–57. – reference: 3) Centers for Disease Control and Prevention (CDC). Fixed obstructive lung disease in workers at a microwave popcorn factory—Missouri, 2000–2002. Morb Mortal Wkly Rep 2002;51:345–7. [Online]. [cited 2021 April 4]; Available from: URL: https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5116a2.htm – reference: 5) Akpinar-Elci M, Travis WD, Lynch DA. Bronchiolitis obliterans syndrome in popcorn production plant workers. Eur Respir J 2004;24:298–302. – reference: 13) Lockey JE, Hilbert TJ, Levin LP. Airway obstruction related to diacetyl exposure at microwave popcorn production facilities. Eur Respir J 2009;34:63–71. – reference: 9) Kanwal R, Kullman G, Fedan KB, Kreiss K. Occupational lung disease risk and exposure to butter-flavoring chemicals after implementation of controls at a microwave popcorn plant. Publ Health Rep 2011;126:480–94. – reference: 20) Martyny JW, Van Dyke MV, Arbuckle S, Towle M, Rose CS. Diacetyl exposures in the flavor manufacturing industry. J Occup Environ Hyg 2008;5:679–88. – reference: 7) Kreiss K, Gomaa A, Kullman GK, Fedan K, Simoes EJ, Enright PL. Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. N Engl J Med 2002;347:330–8. – reference: 15) Centers for Disease Control and Prevention (CDC). Fixed obstructive lung disease among workers in the flavor-manufacturing industry – California, 2004–2007. Morb Mortal Wkly Rep 2007;56:389–93. [Online]. [cited 2021 April 4]; Available from: URL: https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5616a2.htm – reference: 4) Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med 1999;159:179–87. – reference: 1) McKernan LT, Niemeier RT, Kreiss K, et al. Criteria for a recommended standard occupational exposure to diacetyl and 2,3-pentanedione. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health. [Online]. [cited 2021 April 4]; Available from: URL: https://www.cdc.gov/niosh/docs/2016-111/default.html – reference: 6) Kullman G, Boylstein R, Jones W, Piacitelli C, Pendergrass S, Kreiss K. Characterization of respiratory exposures at a microwave popcorn plant with cases of bronchiolitis obliterans. J Occup Environ Hyg 2005;2:169–78. – reference: 23) Hubbs AF, Goldsmith WT, Kashon ML, et al. Respiratory toxicologic pathology of inhaled diacetyl in Sprague-Dawley rats. Toxicol Pathol 2008;36:330–44. – reference: 25) Palmer SM, Flake GP, Kelly FL, et al. Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats. PLoS ONE 2011;6:e17644. – reference: 21) Fechter-Leggett ED, White SK, Fedan KB, Cox-Ganser MC, Cummings KJ. Burden of respiratory abnormalities in microwave popcorn and flavouring manufacturing workers. Occup Environ Med 2018;75:709–15. – reference: 16) Kim TJ, Materna BL, Prudhomme JC, et al. Industry-wide medical surveillance of California flavor manufacturing workers: cross-sectional results. Am J Ind Med 2010;53:857–865. – reference: 27) Pierce JS, Abelmann A, Spicer LJ, Adams RE, Finley BL. Diacetyl and 2,3-pentanedione exposures associated with cigarette smoking: implications for risk assessment of food and flavoring workers. Crit Rev Toxicol 2014;44:420–35. |
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| Snippet | 「I. はじめに」ジアセチル (化学式 C4H6O2) は別名2, 3-ブタンジオンといい, 2つのアセチル基がカルボニル基の炭素同士で結合したジケトンである. 酵母や乳酸菌などの微生物による発酵の際に生成する. 沸点は88℃で揮発性が高く, 強いバター臭があり, 食品香料として使用されている.... |
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| Title | ジアセチル曝露労働者に発症した閉塞性肺疾患 |
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