Expression profiles of TWEAK and Fn14 genes in the duodenal and colonic mucosae of dogs with chronic enteropathy

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a cytokine that binds to fibroblast growth factor-inducible 14 (Fn14). The TWEAK/Fn14 pathway promotes intestinal inflammation, induces C-X-C motif chemokine ligand 10 (CXCL10), and is upregulated in the intestine of humans with inflamm...

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Published inJapanese Journal of Veterinary Research Vol. 71; no. 1; pp. 27 - 34
Main Authors Kimura, Junpei, Shingaki, Tomoaki, Ohmori, Keitaro, Furukawa, Rintaro, Nishimura, Rinka, Hara, Yuna, Kondo, Hirotaka, Furuya, Keiko
Format Journal Article
LanguageEnglish
Published Japanese Journal of Veterinary Research Editorial Committee, Faculty of Veterinary Medicine, Hokkaido University 30.08.2023
Subjects
Chronic enteropathy
Dog
Tumor necrosis factor-like weak inducer of apoptosis
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ISSN0047-1917
2758-447X
DOI10.57494/jjvr.71.1_27

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Summary:Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a cytokine that binds to fibroblast growth factor-inducible 14 (Fn14). The TWEAK/Fn14 pathway promotes intestinal inflammation, induces C-X-C motif chemokine ligand 10 (CXCL10), and is upregulated in the intestine of humans with inflammatory bowel disease. However, the role of this pathway in canine chronic enteropathy (CE) remains unclear. Therefore, we measured TWEAK, Fn14, and CXCL10 mRNA levels in the intestinal mucosa of dogs with CE. Real-time PCR analysis revealed significantly lower TWEAK and CXCL10 mRNA levels in the duodenal mucosa of dogs with antibiotic-responsive enteropathy (ARE), a type of CE, compared to healthy dogs. The findings suggested the involvement of decreased TWEAK and CXCL10 mRNA levels in the ARE etiology.
ISSN:0047-1917
2758-447X
DOI:10.57494/jjvr.71.1_27