Effects of serum amyloid A protein on lymphocytes, HeLa, and MRC5 cells in culture

A major human acute phase protein, the serum amyloid A protein, has been tested in vitro for its effect on lymphocyte proliferation, the formation of E-stable rosettes, as well as the growth of HeLa and MRC5 cell cultures. Serum amyloid A protein has been found to be markedly inhibitory at 30, 100,...

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Bibliographic Details
Published inBiochemistry and cell biology Vol. 67; no. 7; p. 365
Main Authors Peristeris, P, Gaspar, A, Gros, P, Laurent, P, Bernon, H, Bienvenu, J
Format Journal Article
LanguageEnglish
Published Canada 01.07.1989
Subjects
Acute-Phase Reaction - blood
Cell Division - drug effects
Cells, Cultured
Electrophoresis, Polyacrylamide Gel
HeLa Cells
Humans
Inflammation - blood
Lymphocyte Culture Test, Mixed
Lymphocytes - physiology
Rosette Formation
Serum Amyloid A Protein - physiology
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Summary:A major human acute phase protein, the serum amyloid A protein, has been tested in vitro for its effect on lymphocyte proliferation, the formation of E-stable rosettes, as well as the growth of HeLa and MRC5 cell cultures. Serum amyloid A protein has been found to be markedly inhibitory at 30, 100, 200, and 300 micrograms/mL, and is a very potent inhibitor of in vitro biological functions.
ISSN:0829-8211
DOI:10.1139/o89-057