Chemical screening in zebrafish for novel biological and therapeutic discovery
Zebrafish chemical screening allows for an in vivo assessment of small molecule modulation of biological processes. Compound toxicities, chemical alterations by metabolism, pharmacokinetic and pharmacodynamic properties, and modulation of cell niches can be studied with this method. Furthermore, zeb...
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| Published in | Methods in cell biology Vol. 138; pp. 651 - 679 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.01.2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0091-679X |
| DOI | 10.1016/bs.mcb.2016.10.004 |
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| Abstract | Zebrafish chemical screening allows for an in vivo assessment of small molecule modulation of biological processes. Compound toxicities, chemical alterations by metabolism, pharmacokinetic and pharmacodynamic properties, and modulation of cell niches can be studied with this method. Furthermore, zebrafish screening is straightforward and cost effective. Zebrafish provide an invaluable platform for novel therapeutic discovery through chemical screening. |
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| AbstractList | Zebrafish chemical screening allows for an in vivo assessment of small molecule modulation of biological processes. Compound toxicities, chemical alterations by metabolism, pharmacokinetic and pharmacodynamic properties, and modulation of cell niches can be studied with this method. Furthermore, zebrafish screening is straightforward and cost effective. Zebrafish provide an invaluable platform for novel therapeutic discovery through chemical screening. |
| Author | Wiley, D S Zon, L I Redfield, S E |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28129862$$D View this record in MEDLINE/PubMed |
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| Keywords | Hit Phenotype Chemical Chemoinformatic Screen Zebrafish Libraries |
| Language | English |
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| SubjectTerms | Animals Drug Discovery - methods Drug Evaluation, Preclinical - methods Embryo, Nonmammalian - drug effects High-Throughput Screening Assays - methods Humans Small Molecule Libraries - pharmacology Zebrafish - genetics Zebrafish - growth & development |
| Title | Chemical screening in zebrafish for novel biological and therapeutic discovery |
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