Chemical screening in zebrafish for novel biological and therapeutic discovery

Zebrafish chemical screening allows for an in vivo assessment of small molecule modulation of biological processes. Compound toxicities, chemical alterations by metabolism, pharmacokinetic and pharmacodynamic properties, and modulation of cell niches can be studied with this method. Furthermore, zeb...

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Bibliographic Details
Published inMethods in cell biology Vol. 138; pp. 651 - 679
Main Authors Wiley, D S, Redfield, S E, Zon, L I
Format Journal Article
LanguageEnglish
Published United States 01.01.2017
Subjects
Animals
Drug Discovery - methods
Drug Evaluation, Preclinical - methods
Embryo, Nonmammalian - drug effects
High-Throughput Screening Assays - methods
Humans
Small Molecule Libraries - pharmacology
Zebrafish - genetics
Zebrafish - growth & development
Hit
Phenotype
Chemical
Chemoinformatic
Screen
Zebrafish
Libraries
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Summary:Zebrafish chemical screening allows for an in vivo assessment of small molecule modulation of biological processes. Compound toxicities, chemical alterations by metabolism, pharmacokinetic and pharmacodynamic properties, and modulation of cell niches can be studied with this method. Furthermore, zebrafish screening is straightforward and cost effective. Zebrafish provide an invaluable platform for novel therapeutic discovery through chemical screening.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0091-679X
DOI:10.1016/bs.mcb.2016.10.004