EFFECTS OF CHRONIC TREATMENT WITH CAPTOPRIL (SQ 14, 225), AN ORALLY ACTIVE INHIBITOR OF ANGIOTENSIN I-CONVERTING ENZYME, IN SPONTANEOUSLY HYPERTENSIVE RATS

The effects of hydralazine (3 mg/kg) and the angiotensin I-converting enzyme (ACE) inhibitor captopril (SQ 14, 225) (100 mg/kg) on mean arterial blood pressure, plasma renin activity, urinary volume and urinary Na+, K+, and aldosterone concentrations were examined in spontaneously hypertensive rats...

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Published inJapanese journal of pharmacology Vol. 29; no. 2; pp. 285 - 294
Main Authors ANTONACCIO, Michael J., RUBIN, Bernard, HOROVITZ, Zola P., LAFFAN, Robert J., GOLDBERG, Morton E., HIGH, John P., HARRIS, Don N., ZAIDI, I.
Format Journal Article
LanguageEnglish
Published Japan The Japanese Pharmacological Society 01.01.1979
Subjects
Aldosterone - urine
Angiotensin-Converting Enzyme Inhibitors
Animals
Blood Pressure - drug effects
Captopril - administration & dosage
Captopril - pharmacology
Heart - anatomy & histology
Hypertension - blood
Hypertension - physiopathology
Hypertension - urine
Male
Organ Size - drug effects
Potassium - urine
Proline - analogs & derivatives
Rats
Renin - blood
Sodium - urine
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Summary:The effects of hydralazine (3 mg/kg) and the angiotensin I-converting enzyme (ACE) inhibitor captopril (SQ 14, 225) (100 mg/kg) on mean arterial blood pressure, plasma renin activity, urinary volume and urinary Na+, K+, and aldosterone concentrations were examined in spontaneously hypertensive rats of the Okamoto and Aoki strain (SHR) after oral daily dosing for 2 weeks, 3 or 6 months. Captopril caused progressive cumulative reductions in blood pressure resulting in normalization of pressure after 6 months of dosing. Hydralazine also significantly reduced blood pressure but not to the level of normotensive rats of the Wistar-Kyoto strain (WKY). Reductions in heart size paralleled the changes in blood pressure, normalization of cardiac hypertrophy occurring after captopril but not hydralazine. Plasma renin activity increased approximately 2-3 fold after hydralazine and 15-fold after captopril. Neither hydralazine nor captopril had any consistent effects on 24-hr urine volume, urinary Na+, K+ or aldosterone excretion. These results indicate that chronic inhibition of ACE with captopril induces normalization of blood pressure in SHR, a normal-renin model of hypertension.
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ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.29.285