A1‐, A2A‐ and A3‐subtype adenosine receptors modulate intraocular pressure in the mouse

Despite the potential importance of the mouse in studying the pharmacology of aqueous dynamics, measurement of intraocular pressure (IOP) in its very small eye has been problematic. Utilizing a novel servo‐null electrophysiologic approach recently applied to the mouse, we have identified a diversity...

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Bibliographic Details
Published inBritish journal of pharmacology Vol. 134; no. 2; pp. 241 - 245
Main Authors Avila, Marcel Y, Stone, Richard A, Civan, Mortimer M
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.09.2001
Nature Publishing
Subjects
Aqueous humour
Biological and medical sciences
Cl‐IB‐MECA
CPA
DCPCX
Eye and associated structures. Visual pathways and centers. Vision
Fundamental and applied biological sciences. Psychology
glaucoma
IB‐MECA
MRS 1097
MRS 1191
MRS1523
Special Reports
Vertebrates: nervous system and sense organs
ZM241385
A2A adenosine receptor
Vertebrata
Regulation(control)
Mammalia
Mouse
Animal
Rodentia
A1 Adenosine receptor
Aqueous humor
Neuromodulation
A3 adenosine receptor
Intraocular pressure
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Summary:Despite the potential importance of the mouse in studying the pharmacology of aqueous dynamics, measurement of intraocular pressure (IOP) in its very small eye has been problematic. Utilizing a novel servo‐null electrophysiologic approach recently applied to the mouse, we have identified a diversity of adenosine‐receptor mechanisms in modulating IOP in this species. We report the first evidence that A3 receptors increase IOP in any species, and verify in the mouse reports with larger mammals that A1 receptors lower and A2A receptors increase IOP. British Journal of Pharmacology (2001) 134, 241–245; doi:10.1038/sj.bjp.0704267
ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0704267