In situ Monitoring of Drug Action Using Sensors

The application of electrochemical sensors to biochemical analysis is attractive, because the measurement is fast, easy, and continuous in a turbid cell suspension. In addition, the apparatus used is inexpensive. In this paper, we report on how electrochemical sensors, such as oxygen electrode and i...

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Published inBUNSEKI KAGAKU Vol. 62; no. 2; pp. 121 - 130
Main Authors KATSU, Takashi, KOMAGOE, Keiko, MASUDA, Kazufumi, KATO, Hisato, INOUE, Tsuyoshi
Format Journal Article
LanguageJapanese
Published The Japan Society for Analytical Chemistry 2013
Subjects
in situ monitoring
ion sensor
membrane-active drug
oxygen electrode
photoinactivation
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Summary:The application of electrochemical sensors to biochemical analysis is attractive, because the measurement is fast, easy, and continuous in a turbid cell suspension. In addition, the apparatus used is inexpensive. In this paper, we report on how electrochemical sensors, such as oxygen electrode and ion sensors, are useful to analyze the photoinactivation of bacteria induced by dyes. Furthermore, we coupled a K+ sensor with spectrometry. This methodology enabled us to rapidly screen the sizes of pores formed in a liposomal membrane. We also describe a simple method for constructing ion sensors in a laboratory.
ISSN:0525-1931
DOI:10.2116/bunsekikagaku.62.121