Fisher syndrome with delayed facial weakness and taste impairment: a case report

A 55-year-old man was admitted to our hospital because of acute onset of diplopia and gait disturbance. On admission, ophthalmoplegia, ataxia and areflexia were observed. He was diagnosed with Fisher syndrome and given intravenous immunoglobulin therapy from day 6 to day 10 after disease onset. Afte...

Full description

Saved in:
Bibliographic Details
Published inRinsho Shinkeigaku Vol. 56; no. 10; pp. 684 - 689
Main Authors Yamamoto, Daisuke, Suzuki, Syuuichirou, Hirose, Bungo, Yamada, Minoru, Shimizu, Masaki, Shimohama, Shun
Format Journal Article
LanguageJapanese
Published Japan Societas Neurologica Japonica 2016
Subjects
Autoantibodies - blood
Biomarkers - blood
blink reflex
Blinking
Facial Nerve Diseases - diagnosis
Facial Nerve Diseases - etiology
facial palsy
Facial Paralysis - diagnosis
Facial Paralysis - etiology
Fisher syndrome
Gangliosides - immunology
GQ1b antibody
Humans
Immunoglobulins, Intravenous - administration & dosage
Male
Middle Aged
Miller Fisher Syndrome - complications
Miller Fisher Syndrome - diagnosis
Miller Fisher Syndrome - drug therapy
Neural Conduction
Taste Disorders - etiology
taste impairment
Treatment Outcome
Online AccessGet full text

Cover

More Information
Summary:A 55-year-old man was admitted to our hospital because of acute onset of diplopia and gait disturbance. On admission, ophthalmoplegia, ataxia and areflexia were observed. He was diagnosed with Fisher syndrome and given intravenous immunoglobulin therapy from day 6 to day 10 after disease onset. After treatment, ophthalmoplegia and ataxia began to improve. However, he developed taste impairment on day 13 and right hemifacial weakness on day 16 after onset. A blink reflex test revealed right facial nerve impairment. On day 42 after onset, facial weakness and taste impairment remitted, and the blink reflex test result was normalized without additional treatment. Although it has been known that 10% of patients with Fisher syndrome complicated by delayed facial nerve palsy, the mechanism of the facial nerve palsy has not been elucidated. Therefore, this is a significant report to describe delayed facial nerve palsy combined with taste impairment and successive recordings of blink reflex and facial nerve conduction in a patient with Fisher syndrome.
ISSN:0009-918X
1882-0654
DOI:10.5692/clinicalneurol.cn-000910