A highly selective and sensitive fluorescent probe for simultaneously distinguishing and sequentially detecting H2S and various thiol species in solution and in live cells

A novel dual-channel fluorescent probe (NCR) based on differences in reactivity among H2S, Cys/Hcy, and GSH was rationally designed for simultaneously distinguishing and sequentially sensing H2S, Cys/Hcy, and GSH using two emission channels, which also demonstrated that NCR can be used for targeting...

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Published inChemical communications (Cambridge, England) Vol. 54; no. 94; pp. 13252 - 13255
Main Authors Qiao, Dan, Shen, Tangliang, Zhu, Mengyuan, Liang, Xiao, Zhang, Lu, Yin, Zheng, Wang, Binghe, Shang, Luqing
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 2018
Subjects
chemical reactions
fluorescent dyes
Fluorescent indicators
Hydrogen sulfide
mammals
Mitochondria
thiols
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Summary:A novel dual-channel fluorescent probe (NCR) based on differences in reactivity among H2S, Cys/Hcy, and GSH was rationally designed for simultaneously distinguishing and sequentially sensing H2S, Cys/Hcy, and GSH using two emission channels, which also demonstrated that NCR can be used for targeting mitochondria in mammalian cells.
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c8cc07761d