Biochemical mechanisms of glomerular dysfunction and lesions

• Published in: Nihon Jinzo Gakkai shi Vol. 27; no. 9; pp. 1223 - 1228
• Main Author: RICHET, G.
• Format: Journal Article
• Language: English
• Published: Japan Japanese Society of Nephrology 1985
• Subjects: Animals; Culture Techniques; Kidney Diseases - metabolism; Kidney Glomerulus - metabolism; Rats
• ISSN: 0385-2385; 1884-0728
• DOI: 10.14842/jpnjnephrol1959.27.1223

In this Editorial we shall try to show the benefit that could bring a new approach of glomerular pathology that is biochemical studies of isolated glomeruli and cultivated glomerular cells. We shall successively consider the principal biochemical activities of the isolated glomerulus and three precise areas in which biochemical alterations within the isolated glomerulus could play a role : spontaneously reversible acute renal failure, experimental diffuse proliferative glomerulonephritis, chronic rejection of human kidney transplant. We selected these examples for they were studied at Hôpital TENON, Paris, where are gathered three different units of clinical nephrology, experimental pathology and investigative physiology. We are aware that this presentation is too restricted as it does not take into account what was done in the few other research laboratories directly involved in same field. Indeed M. Dunn in Cleveland, T.P. Dousa in Rochester and Y. Orita in Professor Abe's Department in Osaka are the other investigators who followed with their groups the same approach, maybe more physiologically oriented.