Mobile stroke unitとその車載用診断装置の最新動向

最速の脳卒中治療とより良好な患者転帰を目的として,mobile stroke unit(MSU)が欧米を中心に運用されている.MSUは,頭部専用CT装置と遠隔通信装置を備えたドクターカーで,救急要請現場または救急車との合流点で,脳卒中の診断と治療および最適な搬送先決定を行う.MSUによる急性期脳梗塞rt-PA静注療法は2021年,通常救急搬送と比較した前向き試験により,有意に転帰良好であることが報告された.費用対効果の上昇も同様に明らかにされている.日本はMSUに搭載可能なCT装置が未承認であるため,MSU未導入である.今後承認されたとしても,導入および運用に関する巨額なコストなど,財政的な課...

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Published in脳卒中 Vol. 45; no. 5; pp. 369 - 380
Main Authors 三澤, 雅樹, 河野, 豊, 廣木, 昌彦
Format Journal Article
LanguageJapanese
Published 一般社団法人 日本脳卒中学会 2023
日本脳卒中学会
Subjects
Online AccessGet full text
ISSN0912-0726
1883-1923
DOI10.3995/jstroke.11138

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Abstract 最速の脳卒中治療とより良好な患者転帰を目的として,mobile stroke unit(MSU)が欧米を中心に運用されている.MSUは,頭部専用CT装置と遠隔通信装置を備えたドクターカーで,救急要請現場または救急車との合流点で,脳卒中の診断と治療および最適な搬送先決定を行う.MSUによる急性期脳梗塞rt-PA静注療法は2021年,通常救急搬送と比較した前向き試験により,有意に転帰良好であることが報告された.費用対効果の上昇も同様に明らかにされている.日本はMSUに搭載可能なCT装置が未承認であるため,MSU未導入である.今後承認されたとしても,導入および運用に関する巨額なコストなど,財政的な課題が待ち構えている.このことは,特に医療提供の低い地方部・遠隔地へのMSU導入には,大きな障壁である.本論文では,MSUの最新動向と課題解決に向けた現在開発,または検証中の車載用診断装置についてまとめた.
AbstractList 要旨:最速の脳卒中治療とより良好な患者転帰を目的として, mobile stroke unit(MSU)が欧米を中心に運用されている. MSUは, 頭部専用CT装置と遠隔通信装置を備えたドクターカーで, 救急要請現場または救急車との合流点で, 脳卒中の診断と治療および最適な搬送先決定を行う. MSUによる急性期脳梗塞rt-PA静注療法は2021年, 通常救急搬送と比較した前向き試験により, 有意に転帰良好であることが報告された. 費用対効果の上昇も同様に明らかにされている. 日本はMSUに搭載可能なCT装置が未承認であるため, MSU未導入である. 今後承認されたとしても, 導入および運用に関する巨額なコストなど, 財政的な課題が待ち構えている. このことは, 特に医療提供の低い地方部・遠隔地へのMSU導入には, 大きな障壁である. 本論文では, MSUの最新動向と課題解決に向けた現在開発, または検証中の車載用診断装置についてまとめた.
最速の脳卒中治療とより良好な患者転帰を目的として,mobile stroke unit(MSU)が欧米を中心に運用されている.MSUは,頭部専用CT装置と遠隔通信装置を備えたドクターカーで,救急要請現場または救急車との合流点で,脳卒中の診断と治療および最適な搬送先決定を行う.MSUによる急性期脳梗塞rt-PA静注療法は2021年,通常救急搬送と比較した前向き試験により,有意に転帰良好であることが報告された.費用対効果の上昇も同様に明らかにされている.日本はMSUに搭載可能なCT装置が未承認であるため,MSU未導入である.今後承認されたとしても,導入および運用に関する巨額なコストなど,財政的な課題が待ち構えている.このことは,特に医療提供の低い地方部・遠隔地へのMSU導入には,大きな障壁である.本論文では,MSUの最新動向と課題解決に向けた現在開発,または検証中の車載用診断装置についてまとめた.
Author 三澤, 雅樹
河野, 豊
廣木, 昌彦
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CorporateAuthor 駒澤大学医療健康科学部
産業技術総合研究所健康医工学研究部門
いばらき移動診療支援機構
筑波メディカルセンター病院脳神経内科
茨城県立医療大学医科学センター神経内科学
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– name: 駒澤大学医療健康科学部
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12) Excellance: Discover the Mobile Stroke Unit from Excellance. https://excellance.com/discover-the-mobile-stroke-unit-from-excellance
9) Kummer BR, Lerario MP, Hunter MD, et al.: Geographic analysis of mobile stroke unit treatment in a dense urban area: The New York City METRONOME Registry. J Am Heart Assoc 8: e013529, 2019
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16) Mathur S, Walter S, Grunwald IQ, et al.: Improving prehospital stroke services in rural and underserved settings with mobile stroke units. Front Neurol 10: 159, 2019
27) Bowry R, Parker SA, Bratina P, et al.: Hemorrhage enlargement is more frequent in the first 2 hours: a prehospital mobile stroke unit study. Stroke 53: 2352–2360, 2022
13) Walter S, Kostopoulos P, Haass A, et al.: Diagnosis and treatment of patients with stroke in a mobile stroke unit versus in hospital: a randomised controlled trial. Lancet Neurol 11: 397–404, 2012
4) Ebinger M, Siegerink B, Kunz A, et al.: Association between dispatch of mobile stroke units and functional outcomes among patients with acute ischemic stroke in Berlin. JAMA 325: 454–466, 2021
23) Nilanont Y, Chanyagorn P, Shukij K, et al.: Comparing performance measures and clinical outcomes between mobile stroke units and usual care in underserved areas. Neurol Sci 44: 1261–1271, 2023
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35) Lopez-Montes A, McSkimming T, Zbijewski W, et al.: Stationary X-ray tomography for hemorrhagic stroke imaging: sampling and resolution properties. 7th International Conference on Image Formation in X-Ray Computed Tomography. SPIE Proceedings 12304, 2022. https://doi.org/10.1117/12.2646858
7) Dos Santos A, Balabanski A, Cook D, et al.: Electromagnetic portable brain imaging for stroke. Stroke 53(Suppl 1): A129, 2022
31) Coote S, Mackey E, Alexandrov AW, et al.: The mobile stroke unit nurse: an international exploration of their scope of practice, education, and training. J Neurosci Nurs 54: 61–67, 2022
30) Lund UH, Stoinska-Schneider A, Larsen K, et al.: Cost-effectiveness of mobile stroke unit care in Norway. Stroke 53: 3173–3181, 2022
18) Reichenbach K, Mathiesen C, Thomas L, et al.: Reimbursement of mobile stroke units in the United States: a survey by the prehospital stroke treatment organization (PRESTO). Stroke 52 (Suppl 1): AMP19, 2021
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17) Kim J, Easton D, Zhao H, et al.: Economic evaluation of the Melbourne mobile stroke unit. Int J Stroke 16: 466–475, 2021
40) EMVision: Products. https://emvision.com.au/products/(アクセス日:2023年3月3日
25) Mobile stroke unit news: PRESTO Newsletter 4: 1–9, 2023 https://prestomsu.org/files/Newsletters/PRESTO_Newsletter_V4N1_Final_12-6-2022.pdf(アクセス日:2023年1月4日
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36) 宮川道夫:マイクロ波イメージング.映像情報メディア学会誌 67: 468–472, 2013
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– reference: 16) Mathur S, Walter S, Grunwald IQ, et al.: Improving prehospital stroke services in rural and underserved settings with mobile stroke units. Front Neurol 10: 159, 2019
– reference: 27) Bowry R, Parker SA, Bratina P, et al.: Hemorrhage enlargement is more frequent in the first 2 hours: a prehospital mobile stroke unit study. Stroke 53: 2352–2360, 2022
– reference: 30) Lund UH, Stoinska-Schneider A, Larsen K, et al.: Cost-effectiveness of mobile stroke unit care in Norway. Stroke 53: 3173–3181, 2022
– reference: 4) Ebinger M, Siegerink B, Kunz A, et al.: Association between dispatch of mobile stroke units and functional outcomes among patients with acute ischemic stroke in Berlin. JAMA 325: 454–466, 2021
– reference: 32) SIEMENS Healthineers: SOMATOM Scope. https://www.siemens-healthineers.com/en-us/computed-tomography/ecoline-refurbished-systems/somatom-scope(アクセス日:2023年1月4日)
– reference: 44) Medfield Diagnostics: Products. https://www.medfielddiagnostics.com/products/(アクセス日:2023年3月4日)
– reference: 12) Excellance: Discover the Mobile Stroke Unit from Excellance. https://excellance.com/discover-the-mobile-stroke-unit-from-excellance/
– reference: 5) Grotta JC, Yamal JM, Parker SA, et al.: Prospective, multicenter, controlled trial of mobile stroke units. N Engl J Med 385: 971–981, 2021
– reference: 31) Coote S, Mackey E, Alexandrov AW, et al.: The mobile stroke unit nurse: an international exploration of their scope of practice, education, and training. J Neurosci Nurs 54: 61–67, 2022
– reference: 37) 総務省:電波利用ホームページ,電波防護指針.電気通信技術審議会答申諮問第38号「電波利用における人体の防護指針」(平成2年6月)https://www.tele.soumu.go.jp/j/sys/ele/medical/protect/(アクセス日:2023年1月17日)
– reference: 35) Lopez-Montes A, McSkimming T, Zbijewski W, et al.: Stationary X-ray tomography for hemorrhagic stroke imaging: sampling and resolution properties. 7th International Conference on Image Formation in X-Ray Computed Tomography. SPIE Proceedings 12304, 2022. https://doi.org/10.1117/12.2646858
– reference: 46) Hood R, Persson M, Fhager A, et al.: Evaluating the sensitivity and specificity of a microwave based tool to support and enhance stroke triage. Int J Stroke 17: 64–65, 2022
– reference: 3) Navi BB, Audebert HJ, Alexandrov AW, et al.: Mobile stroke units: evidence, gaps, and next steps. Stroke 53: 2103–2113, 2022
– reference: 42) EMTensor: EMTensor BrainScanner. https://www.emtensor.com/(アクセス日:2023年3月4日)
– reference: 17) Kim J, Easton D, Zhao H, et al.: Economic evaluation of the Melbourne mobile stroke unit. Int J Stroke 16: 466–475, 2021
– reference: 39) Cook D, Brown H, Widanapathirana I, et al.: Case Report: Preliminary images from an electromagnetic portable brain scanner for diagnosis and monitoring of acute stroke. Front Neurol 12: 765412, 2021
– reference: 33) MICRO-X: Brain CT scanner. https://micro-x.com/products/ct-brain-scanner/(アクセス日:2023年1月4日)
– reference: 21) New Atlas. Japanese EMTs to start using AR glasses while transporting patients. https://newatlas.com/vr/japanese-emts-vuzix-ar-glasses/(アクセス日:2023年3月23日)
– reference: 29) Chen J, Lin X, Cai Y, et al.: A systematic review of mobile stroke unit among acute stroke patients: time metrics, adverse events, functional result and cost-effectiveness. Front Neurol 13: 803162, 2022. doi: 10.3389/fneur.2022.803162
– reference: 23) Nilanont Y, Chanyagorn P, Shukij K, et al.: Comparing performance measures and clinical outcomes between mobile stroke units and usual care in underserved areas. Neurol Sci 44: 1261–1271, 2023
– reference: 7) Dos Santos A, Balabanski A, Cook D, et al.: Electromagnetic portable brain imaging for stroke. Stroke 53(Suppl 1): A129, 2022
– reference: 38) Alqadami A, Zamani A, Trakic A, et al.: Flexible electromagnetic cap for three-dimensional electromagnetic head imaging. IEEE Trans Biomed Eng 68: 2880–2891, 2021
– reference: 6) 廣木昌彦,河野元嗣,三澤雅樹:Mobile Stroke Unitに関する全国アンケート調査 —課題と展望—.日臨救急医会誌 25: 694–703, 2022
– reference: 26) Bivard A, Zhao H, Churilov L, et al.: Comparison of tenecteplase with alteplase for the early treatment of ischaemic stroke in the Melbourne Mobile Stroke Unit (TASTE-A): a phase 2, randomised, open-label trial. Lancet Neurol 21: 520–527, 2022
– reference: 36) 宮川道夫:マイクロ波イメージング.映像情報メディア学会誌 67: 468–472, 2013
– reference: 28) Rohmann JL, Piccininni M, Ebinger M, et al.: Effect of mobile stroke unit dispatch in all patients with acute stroke or TIA. Ann Neurol 93: 50–63, 2023
– reference: 10) Audebert H, Fassbender K, Hussain MS, et al.: The PRE-hospital Stroke Treatment Organization. Int J Stroke 12: 932–940, 2017
– reference: 18) Reichenbach K, Mathiesen C, Thomas L, et al.: Reimbursement of mobile stroke units in the United States: a survey by the prehospital stroke treatment organization (PRESTO). Stroke 52 (Suppl 1): AMP19, 2021
– reference: 25) Mobile stroke unit news: PRESTO Newsletter 4: 1–9, 2023 https://prestomsu.org/files/Newsletters/PRESTO_Newsletter_V4N1_Final_12-6-2022.pdf(アクセス日:2023年1月4日)
– reference: 2) 廣木昌彦,河野元嗣,三澤雅樹:MSUの日本への導入と運用における問題点と展望.日臨救急医会誌 25: 767–781, 2022
– reference: 41) Al-Saffar A, Guo L, Abbosh A: Introducing: DeepHead, a wide-band electromagnetic imaging paradigm. Trans Comput Imaging. Preprint. (2021). https://arxiv.org/abs/2107.11107(アクセス日:2023年1月4日)
– reference: 13) Walter S, Kostopoulos P, Haass A, et al.: Diagnosis and treatment of patients with stroke in a mobile stroke unit versus in hospital: a randomised controlled trial. Lancet Neurol 11: 397–404, 2012
– reference: 11) NeuroLogica: Mobile CT. https://www.neurologica.com/(アクセス日:2023年1月4日)
– reference: 19) Calderon VJ, Kasturiarachi BM, Lin E, et al.: Review of the mobile stroke unit experience worldwide. Interv Neurol 7: 347–358, 2018
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Snippet 最速の脳卒中治療とより良好な患者転帰を目的として,mobile stroke...
要旨:最速の脳卒中治療とより良好な患者転帰を目的として, mobile stroke unit(MSU)が欧米を中心に運用されている. MSUは, 頭部専用CT装置と遠隔通信装置を備えたドクターカーで, 救急要請現場または救急車との合流点で, 脳卒中の診断と治療および最適な搬送先決定を行う....
SourceID medicalonline
jstage
SourceType Publisher
StartPage 369
SubjectTerms microwave
mobile stroke unit
prehospital
telemedicine
tomosynthesis
Title Mobile stroke unitとその車載用診断装置の最新動向
URI https://www.jstage.jst.go.jp/article/jstroke/45/5/45_11138/_article/-char/ja
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Volume 45
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ispartofPNX 脳卒中, 2023, Vol.45(5), pp.369-380
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