ヒト子宮頸癌培養細胞におけるfibroblast growth factor (FGF) -10の発現と細胞内情報伝達経路の検討
子宮癌は本邦における女性の全癌死亡数の47%を占め, その内, 子宮頸癌は70%以上であることが知られている. さらに子宮頸癌の90%は扁平上皮癌であり, これらが産生する塩基性線維芽細胞増殖因子(basic fibroblast growth factor(basic FGF)やplatelet-derived endothelial cell growth factor(PD-ECGF), vascular endothelial growth factor(VEGF)などの細胞増殖因子が, 癌細胞の増殖, 進展に関与していることが現在までに報告されている. ヘパリン結合型の細胞増殖因子で...
Saved in:
| Published in | Journal of Nippon Medical School Vol. 68; no. 3; pp. 253 - 258 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本医科大学医学会
2001
|
| Online Access | Get full text |
| ISSN | 1345-4676 1347-3409 |
| DOI | 10.1272/jnms.68.253 |
Cover
| Abstract | 子宮癌は本邦における女性の全癌死亡数の47%を占め, その内, 子宮頸癌は70%以上であることが知られている. さらに子宮頸癌の90%は扁平上皮癌であり, これらが産生する塩基性線維芽細胞増殖因子(basic fibroblast growth factor(basic FGF)やplatelet-derived endothelial cell growth factor(PD-ECGF), vascular endothelial growth factor(VEGF)などの細胞増殖因子が, 癌細胞の増殖, 進展に関与していることが現在までに報告されている. ヘパリン結合型の細胞増殖因子である線維芽細胞増殖因子グループは塩基配列の相同性から, 酸性線維芽細胞増殖因子(acidic FGF, FGF-1), basic FGF(FGF-2), int-2(FGF-3), hst/K-FGF(FGF-4), FGF-5, FGF-6, FGF-7, androgen-induced growth factor(AIGF, FGF-8), glia-activating factor(GAF, FGF-9), FGF-10, FGF-11(FGF homologous factor-3, FHF-3), FGF-12(FHF-1), FGF-13(FHF-2), FGF-14(FHF-4), FGF-15, 16, 17, 18, 19が報告されている. |
|---|---|
| AbstractList | 子宮癌は本邦における女性の全癌死亡数の47%を占め, その内, 子宮頸癌は70%以上であることが知られている. さらに子宮頸癌の90%は扁平上皮癌であり, これらが産生する塩基性線維芽細胞増殖因子(basic fibroblast growth factor(basic FGF)やplatelet-derived endothelial cell growth factor(PD-ECGF), vascular endothelial growth factor(VEGF)などの細胞増殖因子が, 癌細胞の増殖, 進展に関与していることが現在までに報告されている. ヘパリン結合型の細胞増殖因子である線維芽細胞増殖因子グループは塩基配列の相同性から, 酸性線維芽細胞増殖因子(acidic FGF, FGF-1), basic FGF(FGF-2), int-2(FGF-3), hst/K-FGF(FGF-4), FGF-5, FGF-6, FGF-7, androgen-induced growth factor(AIGF, FGF-8), glia-activating factor(GAF, FGF-9), FGF-10, FGF-11(FGF homologous factor-3, FHF-3), FGF-12(FHF-1), FGF-13(FHF-2), FGF-14(FHF-4), FGF-15, 16, 17, 18, 19が報告されている. |
| Author | 石渡, 俊行 山田, 宣孝 川原, 清子 古力娜尓, 庫尓班 藤井, 雄文 呂, 月平 内藤, 善哉 浅野, 伍朗 |
| Author_xml | – sequence: 1 fullname: 内藤, 善哉 organization: 日本医科大学病理学第2教室 – sequence: 1 fullname: 山田, 宣孝 organization: 日本医科大学病理学第2教室 – sequence: 1 fullname: 古力娜尓, 庫尓班 organization: 日本医科大学病理学第2教室 – sequence: 1 fullname: 呂, 月平 organization: 日本医科大学病理学第2教室 – sequence: 1 fullname: 川原, 清子 organization: 日本医科大学病理学第2教室 – sequence: 1 fullname: 藤井, 雄文 organization: 日本医科大学病理学第2教室 – sequence: 1 fullname: 浅野, 伍朗 organization: 日本医科大学病理学第2教室 – sequence: 1 fullname: 石渡, 俊行 organization: 日本医科大学病理学第2教室 |
| BookMark | eNo1kE1L3FAUhi-iUKuu-gdmaReZnvuRm8yuIp2pILip68vN9UYTMokkESl0E4eRolK1dCPUj4ULQRxbUFpF_DMxZuZfNNNpN-c9cM77HM77Eo2HUagReoWhjolF3vhhO6lzu05MOoYmMWWWQRk0xv_2psG4xV-gmSTxHACKMcXAJ9GnvPM173wurg6KXm9w9rs82itO7wbnO-XNj37nJM8u82wnzw7zrV3Xc-LICWSS1lbjaDNdq7lSpVFcm222mq9rBoY865VH9-X-Y55djPzFdve50y3Ofj49HA-yb-XtXv_XdbX2fP69f_FlGk24Mkj0zD-dQsvNdx_m3xuLS62F-blFw6eYgMFBgs1NTbHdYK5uKM216RLmgFKMcEeRBnO0ZVuEYaf63rIBU0uZpgRuWprSKdQacdt6xVMyiMLAC7Xwo404rO4KtYn9qEpPEAAsALgNdCgCKtqw2FVaDBirSG9HJD9J5aoW67HXlvFHIePUU0GFHFK4LeioDO3_R2pNxsKX9A9qIaDm |
| ContentType | Journal Article |
| Copyright | 2001 日本医科大学医学会 |
| Copyright_xml | – notice: 2001 日本医科大学医学会 |
| CorporateAuthor | 日本医科大学病理学第教室 |
| CorporateAuthor_xml | – name: 日本医科大学病理学第教室 |
| DOI | 10.1272/jnms.68.253 |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1347-3409 |
| EndPage | 258 |
| ExternalDocumentID | cw1jonms_2001_006803_006_0253_02581314044 article_jnms_68_3_68_3_253_article_char_ja |
| GroupedDBID | .55 29L 2WC 53G 5GY ABDBF ACUHS AEGXH AENEX ALMA_UNASSIGNED_HOLDINGS CS3 DIK DU5 E3Z EBD EBS EJD EMOBN ESX F5P FRP GX1 JMI JSF JSH KQ8 MK0 MOJWN OVT RJT RNS RZJ SV3 TKC TR2 TUS W2D X7M XSB ~8M |
| ID | FETCH-LOGICAL-j3120-60a0865e31894fe9ce6e5f24b0cc426bc294be787241b253780137c55a0657e33 |
| ISSN | 1345-4676 |
| IngestDate | Thu Jul 10 16:11:57 EDT 2025 Wed Sep 03 06:30:12 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j3120-60a0865e31894fe9ce6e5f24b0cc426bc294be787241b253780137c55a0657e33 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/jnms/68/3/68_3_253/_article/-char/ja |
| PageCount | 6 |
| ParticipantIDs | medicalonline_journals_cw1jonms_2001_006803_006_0253_02581314044 jstage_primary_article_jnms_68_3_68_3_253_article_char_ja |
| PublicationCentury | 2000 |
| PublicationDate | 20010000 |
| PublicationDateYYYYMMDD | 2001-01-01 |
| PublicationDate_xml | – year: 2001 text: 20010000 |
| PublicationDecade | 2000 |
| PublicationTitle | Journal of Nippon Medical School |
| PublicationTitleAlternate | 日医大誌 |
| PublicationYear | 2001 |
| Publisher | 日本医科大学医学会 |
| Publisher_xml | – name: 日本医科大学医学会 |
| References | 12) Hu MC, Qiu WR, Wang YP, Hill D, Ring BD, Scully S, Bolon B, DeRose M, Luethy R, Simonet WS, Arakawa T, Danilenko DM: FGF-18 a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation. Mol Cell Biol 1998; 18: 6063-6074. 11) Hoshikawa M, Ohbayashi N, Yonamine A, Konishi M, Ozaki K, Fukui S, Itoh N: Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain. Biochem Biophys Res Com 1998; 244: 187-191. 26) 細根 勝, 石渡, 俊行, 野村 信夫, 川並 汪一: ヒト乳頭腫ウイルスの局在に関する分子病理学的検討. J Nippon Med Sch 1995; 62: 39-49. 19) Siegfried S, Pekonen F, Nyman T, Ammala M: Expression of mRNA for keratinocyte growth factor and its receptor in human endometrium. Acta Obstet Gynecol Scand 1995; 74: 410-414. 1) 厚生省大臣官房統計情報部 (編) : 平成 7 年人口統計上巻, 1997, pp270-285, 厚生統計協会, 東京. 17) Siegfried S, Pekonen F, Nyman T, Ammala M, Rutanen E-M: Distinct patterns of expression of keratinocyte growth factor and its receptor in endometrial carcinoma. Cancer 1997; 79: 1166-1171. 4) Santin AD, Hermonat PL, Ravaggi A, Pecorelli S, Cannon MJ, Parham GP: Secretion of vascular endothelial growth factor in adenocarcinoma and squamous cell carcinoma of the uterine cervix. Obstet Gynecol 1999; 94: 78-82. 18) Matsui H, Taga M, Kurogi K, Minaguchi H: Gene expression of keratinocyte growth factor and its receptor in the human endometrium/decidua and chorionic villi. Endocrinol J 1997; 44: 867-871. 8) Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SHC, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J: Fibroblast growth factor (FGF) homologous factors: New members of the FGF family implicated in nervous system development. Proc Natl Acad Sci USA 1996; 93: 9850-9857. 27) Bosch FX, Manos MM, Munoz N, Sherman M, Jansen AM, Peto J, Schiffman MH, Moreno V, Kurman R, Shah KV: Prevalence of human papillomavirus in cervical cancer: A worldwide perspective. J Natl Cancer Inst 1995; 87: 796-802. 21) Watanabe M, Ishiwata T, Nishigai K, Moriyama Y, Asano G: Overexpression of keratinocyte growth factor in cancer cells and enterochromaffin cells in human colorectal cancer. Pathol Int 2000; 50: 363-372. 10) Miyake A, Konishi M, Martin FH, Hernday NA, Ozaki K, Yamamoto S, Mikami T, Arakawa T, Itoh N: Structure and expression of a novel member, FGF-16, of the fibroblast growth factor family. Biochem Biophys Res Com 1998; 243: 148-152. 16) BeerHD, Florence C, Dammeier J, McGuire L, Werner S, Duan DR: Mouse fibroblast growth factor 10: cDNA cloning, protein characterization, and regulation of mRNA expression. Oncogene 1997; 15: 2211-2218. 22) Finch PW, Murphy F, Cordinale I, Krueger JG: Altered expression of keratinocyte growth factor and its receptor in psoriasis. Am J Pathol 1997; 151: 1619-1628. 9) McWhirter JR, Goulding M, Weiner JA, Chun J, Murre C: A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. Development 1997; 124: 3221-3232. 28) Kornmann M, Ishiwata T, Beger HG, Korc M: Fibroblast growth factor-5 stimulates mitogenic signaling and is overexpressed in human pancreatic cancer: Evidence for antocrine and paracrine actions. Oncogene 1997; 15: 1417-1424. 14) Yamasaki M, Miyake A, Tagashira S, Itoh N: Structure and expression of the rat mRNA encoding a novel member of the fibroblast growth factor family. J Biol Chem 1996; 271: 15918-15921. 23) Xia YP, Zhao Y, Marcus J, Jimenez PA, Ruben SM, Moore PA, Khan F, Mustoe TA: Effects of keratinocyte growth factor-2 (KGF-2) on wound healing in an ischaemia-impaired rabbit ear model and on scar formation. J Pathol 1999; 188: 431-438. 24) Guo L, Degenstein L, Fuchs E: Keratinocyte growth factor is required for hair development, but not for wound healing. Genes Dev 1996; 10: 165-175. 15) Emoto H, Tagashira S, Mattei MG, Yamasaki M, Hashimoto G, Katsumata T, Negoro T, Nakatsuka M, Birrbaum D, Coulier F, Itoh N: Structure and expression of human fibroblast growth factor-10. J Biol Chem 1997; 272: 23191-23194. 3) Fujimoto J, Sakaguchi H, Hirose R, Ichigo S, Tamaya T: Expression of vascular endothelial growth factor (VEGF) and its mRNA in uterine cervical cancers. Br J Cancer 1999; 80: 827-833. 2) 富永 祐民, 大島 明, 黒石 哲生, 青木 國雄: がん·統計白書-罹患/死亡/予後-1999. 1999; pp1-84, 篠原出版, 東京. 5) Kodama J, Seki N, Tokumo K, Hongo A, Miyagi Y, Yoshinouchi M, Okuda H, Kudo T: Vascular endothelial growth factor is implicated in early invasion in cervical cancer. Eur J Cancer 1999; 35: 485-489. 6) Fujimoto J, Ichigo S, Hori M, Hirose R, Sakaguchi H, Tamaya T: Expression of basic fibroblast growth factor and its mRNA in advanced uterine cervical cancers. Cancer Lett 1997; 111: 21-26. 13) Nishimura T, Utsunomiya Y, Hoshikawa M, Ohuchi H, Itoh N: Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain. Biochem Biophys Acta 1999; 1444: 148-151. 25) Min H, Danilenko DM, Scully SA, Bolon B, Ring BD, Tarpley JE, DeRose M, Simonet WS: Fgf-10is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev 1998; 12: 3156-3161. 7) Fujimoto J, Ichigo S, Sakaguchi H, Hirose R, Tamaya T: Expression of platelet-derived endothelial cell growth factor (PD-ECGF) and its mRNA in uterine cervical cancers. Br J Cancer 1999; 79: 1249-1254. 20) Chen C, Spencer TE, Bazer FW: Fibroblast growth factor-10: A stromal mediator of epithelial function in the ovine uterus. Biol Reprod 2000; 63: 959-966. |
| References_xml | – reference: 23) Xia YP, Zhao Y, Marcus J, Jimenez PA, Ruben SM, Moore PA, Khan F, Mustoe TA: Effects of keratinocyte growth factor-2 (KGF-2) on wound healing in an ischaemia-impaired rabbit ear model and on scar formation. J Pathol 1999; 188: 431-438. – reference: 28) Kornmann M, Ishiwata T, Beger HG, Korc M: Fibroblast growth factor-5 stimulates mitogenic signaling and is overexpressed in human pancreatic cancer: Evidence for antocrine and paracrine actions. Oncogene 1997; 15: 1417-1424. – reference: 15) Emoto H, Tagashira S, Mattei MG, Yamasaki M, Hashimoto G, Katsumata T, Negoro T, Nakatsuka M, Birrbaum D, Coulier F, Itoh N: Structure and expression of human fibroblast growth factor-10. J Biol Chem 1997; 272: 23191-23194. – reference: 16) BeerHD, Florence C, Dammeier J, McGuire L, Werner S, Duan DR: Mouse fibroblast growth factor 10: cDNA cloning, protein characterization, and regulation of mRNA expression. Oncogene 1997; 15: 2211-2218. – reference: 27) Bosch FX, Manos MM, Munoz N, Sherman M, Jansen AM, Peto J, Schiffman MH, Moreno V, Kurman R, Shah KV: Prevalence of human papillomavirus in cervical cancer: A worldwide perspective. J Natl Cancer Inst 1995; 87: 796-802. – reference: 10) Miyake A, Konishi M, Martin FH, Hernday NA, Ozaki K, Yamamoto S, Mikami T, Arakawa T, Itoh N: Structure and expression of a novel member, FGF-16, of the fibroblast growth factor family. Biochem Biophys Res Com 1998; 243: 148-152. – reference: 9) McWhirter JR, Goulding M, Weiner JA, Chun J, Murre C: A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. Development 1997; 124: 3221-3232. – reference: 19) Siegfried S, Pekonen F, Nyman T, Ammala M: Expression of mRNA for keratinocyte growth factor and its receptor in human endometrium. Acta Obstet Gynecol Scand 1995; 74: 410-414. – reference: 22) Finch PW, Murphy F, Cordinale I, Krueger JG: Altered expression of keratinocyte growth factor and its receptor in psoriasis. Am J Pathol 1997; 151: 1619-1628. – reference: 3) Fujimoto J, Sakaguchi H, Hirose R, Ichigo S, Tamaya T: Expression of vascular endothelial growth factor (VEGF) and its mRNA in uterine cervical cancers. Br J Cancer 1999; 80: 827-833. – reference: 25) Min H, Danilenko DM, Scully SA, Bolon B, Ring BD, Tarpley JE, DeRose M, Simonet WS: Fgf-10is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev 1998; 12: 3156-3161. – reference: 11) Hoshikawa M, Ohbayashi N, Yonamine A, Konishi M, Ozaki K, Fukui S, Itoh N: Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain. Biochem Biophys Res Com 1998; 244: 187-191. – reference: 24) Guo L, Degenstein L, Fuchs E: Keratinocyte growth factor is required for hair development, but not for wound healing. Genes Dev 1996; 10: 165-175. – reference: 2) 富永 祐民, 大島 明, 黒石 哲生, 青木 國雄: がん·統計白書-罹患/死亡/予後-1999. 1999; pp1-84, 篠原出版, 東京. – reference: 8) Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SHC, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J: Fibroblast growth factor (FGF) homologous factors: New members of the FGF family implicated in nervous system development. Proc Natl Acad Sci USA 1996; 93: 9850-9857. – reference: 14) Yamasaki M, Miyake A, Tagashira S, Itoh N: Structure and expression of the rat mRNA encoding a novel member of the fibroblast growth factor family. J Biol Chem 1996; 271: 15918-15921. – reference: 26) 細根 勝, 石渡, 俊行, 野村 信夫, 川並 汪一: ヒト乳頭腫ウイルスの局在に関する分子病理学的検討. J Nippon Med Sch 1995; 62: 39-49. – reference: 4) Santin AD, Hermonat PL, Ravaggi A, Pecorelli S, Cannon MJ, Parham GP: Secretion of vascular endothelial growth factor in adenocarcinoma and squamous cell carcinoma of the uterine cervix. Obstet Gynecol 1999; 94: 78-82. – reference: 12) Hu MC, Qiu WR, Wang YP, Hill D, Ring BD, Scully S, Bolon B, DeRose M, Luethy R, Simonet WS, Arakawa T, Danilenko DM: FGF-18 a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation. Mol Cell Biol 1998; 18: 6063-6074. – reference: 20) Chen C, Spencer TE, Bazer FW: Fibroblast growth factor-10: A stromal mediator of epithelial function in the ovine uterus. Biol Reprod 2000; 63: 959-966. – reference: 13) Nishimura T, Utsunomiya Y, Hoshikawa M, Ohuchi H, Itoh N: Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain. Biochem Biophys Acta 1999; 1444: 148-151. – reference: 21) Watanabe M, Ishiwata T, Nishigai K, Moriyama Y, Asano G: Overexpression of keratinocyte growth factor in cancer cells and enterochromaffin cells in human colorectal cancer. Pathol Int 2000; 50: 363-372. – reference: 5) Kodama J, Seki N, Tokumo K, Hongo A, Miyagi Y, Yoshinouchi M, Okuda H, Kudo T: Vascular endothelial growth factor is implicated in early invasion in cervical cancer. Eur J Cancer 1999; 35: 485-489. – reference: 18) Matsui H, Taga M, Kurogi K, Minaguchi H: Gene expression of keratinocyte growth factor and its receptor in the human endometrium/decidua and chorionic villi. Endocrinol J 1997; 44: 867-871. – reference: 6) Fujimoto J, Ichigo S, Hori M, Hirose R, Sakaguchi H, Tamaya T: Expression of basic fibroblast growth factor and its mRNA in advanced uterine cervical cancers. Cancer Lett 1997; 111: 21-26. – reference: 7) Fujimoto J, Ichigo S, Sakaguchi H, Hirose R, Tamaya T: Expression of platelet-derived endothelial cell growth factor (PD-ECGF) and its mRNA in uterine cervical cancers. Br J Cancer 1999; 79: 1249-1254. – reference: 1) 厚生省大臣官房統計情報部 (編) : 平成 7 年人口統計上巻, 1997, pp270-285, 厚生統計協会, 東京. – reference: 17) Siegfried S, Pekonen F, Nyman T, Ammala M, Rutanen E-M: Distinct patterns of expression of keratinocyte growth factor and its receptor in endometrial carcinoma. Cancer 1997; 79: 1166-1171. |
| SSID | ssib003113106 ssib002484297 ssib000959778 ssib015835743 ssj0033556 |
| Score | 1.5721197 |
| Snippet | 子宮癌は本邦における女性の全癌死亡数の47%を占め, その内, 子宮頸癌は70%以上であることが知られている. さらに子宮頸癌の90%は扁平上皮癌であり, これらが産生する塩基性線維芽細胞増殖因子(basic fibroblast growth factor(basic FGF)やplatelet-derived... |
| SourceID | medicalonline jstage |
| SourceType | Publisher |
| StartPage | 253 |
| Title | ヒト子宮頸癌培養細胞におけるfibroblast growth factor (FGF) -10の発現と細胞内情報伝達経路の検討 |
| URI | https://www.jstage.jst.go.jp/article/jnms/68/3/68_3_253/_article/-char/ja http://mol.medicalonline.jp/library/journal/download?GoodsID=cw1jonms/2001/006803/006&name=0253-0258j |
| Volume | 68 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Journal of Nippon Medical School, 2001, Vol.68(3), pp.253-258 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpR3bahQxdGgriCDiFe_sgwFFts4tmeTNme1si2CfWujbsDM7oy60W-wWoW_rUpFavOFLwUsf-lAQq4LiBfFTfBm32_6F5ySzu1OsUBWWkE3Oybklk5OZ5ETTLiSGyXiV2UU9kUG1q2ZRmHpYDKEsZNUoCiO5QXacjU3a16bo1MDgj9yupflGOBwt7Hqu5F-sCmVgVzwl-xeW7TUKBZAH-0IKFoZ0TzYmvkW4RYSZZTgnPiXuCBG6zPj48wVxdeJBlUOEILyEVaJMPCGrwJd0scqziQdYXDboywYN4npZBmFkRhgyYxLuJbDSrofgfTcu34DFfONmdnkP-Kzl0TIxBTx8u-34GXVP0uJAvUeC70adEs4Ip8RnUi4qxQEpgDpAlogYQeaRH1uiUykXJ55D3HKOKEMBhawCQtz_gy8-fmt2tt7_aqVCk3b7ouSmjA1hxiXCk9xw2S5FvoWVhwUZXa9Xk8nbD3spNQEKsJA7MIurZCpLHcu_vJRvDjQO6gZYIKcMDJbzrB2va_ovaiQgKIFmGK7kEZTjeUjYdaQFKUoDedVbXJaD6ZUoPbu5WcuyaRFmPJaf1hjPDV8rP0ep6MyZu2OqyPm_zaSmg5F5azPTc8OMD_dwdoQmj-4YtTpA4F2mRiCvcbECuVES4DHhhoXhm-xBbZ_pOAZuuR2dyi0_BEY_zC33DYDvf_U3KCwPHLvnWVngG8vTgl1xs_O2wOqVHKPgS9ZgZYUhMw5Oq36jos7kHMeJw9qhrJcVXDV8j2gDtcpRbf_1bE_LMW0hbT1NW_fbbx63Nza2Vz93Vpbbr75sry11Przbar1Mm6_T5lLafJLefdAfcQU14gpqxF2E8XYJRlva3OisfO08-p421xV2-97iZmuxvfr-57cX281nnY_LW5_eAtjm2vOt9YfHtcmyP1EaK2Y3ohRrloHvefSKzhnF7xbCTmIRxSymiWmHehSBqx1GprDDGOZg8MtDUIXDMaJoRGkFVhpObFkntKGZ-kx8UisAOo14nFQdwK8wGhqVpGqLxDGNyEn0yilNKC0GsyrsTZA95gJUdcB4YKkETd2twpOiQQ1wr-5QfJA9M-eCPfeY0__fxBntgNowir-z2lDj9nx8DlYQjfC87Ia_AKW09P4 |
| linkProvider | Geneva Foundation for Medical Education and Research |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E3%83%92%E3%83%88%E5%AD%90%E5%AE%AE%E9%A0%B8%E7%99%8C%E5%9F%B9%E9%A4%8A%E7%B4%B0%E8%83%9E%E3%81%AB%E3%81%8A%E3%81%91%E3%82%8Bfibroblast+growth+factor%28FGF%29-10%E3%81%AE%E7%99%BA%E7%8F%BE%E3%81%A8%E7%B4%B0%E8%83%9E%E5%86%85%E6%83%85%E5%A0%B1%E4%BC%9D%E9%81%94%E7%B5%8C%E8%B7%AF%E3%81%AE%E6%A4%9C%E8%A8%8E&rft.jtitle=Journal+of+Nippon+Medical+School&rft.au=%E5%8F%A4%E5%8A%9B%E5%A8%9C%E5%B0%93&rft.au=%E5%BA%AB%E5%B0%93%E7%8F%AD&rft.au=%E7%9F%B3%E6%B8%A1%E4%BF%8A%E8%A1%8C&rft.au=%E5%91%82%E6%9C%88%E5%B9%B3&rft.date=2001&rft.pub=%E6%97%A5%E6%9C%AC%E5%8C%BB%E7%A7%91%E5%A4%A7%E5%AD%A6%E5%8C%BB%E5%AD%A6%E4%BC%9A&rft.issn=1345-4676&rft.volume=68&rft.issue=3&rft.spage=253&rft.epage=258&rft_id=info:doi/10.1272%2Fjnms.68.253&rft.externalDocID=cw1jonms_2001_006803_006_0253_02581314044 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1345-4676&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1345-4676&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1345-4676&client=summon |