Silver-catalyzed oxidative decarboxylation of difluoroacetates: efficient access to C-CF2 bond formation

A mild, versatile and efficient method for the silver(I)-catalyzed oxidative decarboxylative gem-difluoromethylenation has been developed. The radical cascade reaction comprises the addition of an oxidatively generated difluoromethylene radical to the isonitrile functionality and subsequent homolyti...

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Published inChemical communications (Cambridge, England) Vol. 52; no. 8; pp. 1598 - 1601
Main Authors Wan, Wen, Ma, Guobin, Li, Jialiang, Chen, Yunrong, Hu, Qingyang, Li, Minjie, Jiang, Haizhen, Deng, Hongmei, Hao, Jian
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2016
Subjects
Chemistry
Chemistry, Multidisciplinary
decarboxylation
homolytic cleavage
Physical Sciences
Science & Technology
silver
ARYL BORONIC ACIDS
PHENANTHRIDINE DERIVATIVES
DIFLUOROMETHYL
PHOTOREDOX
ISOCYANIDES
DIFLUOROALKYLATION
CYCLIZATION
CARBOXYLIC-ACIDS
BENZOIC-ACIDS
TRIFLUOROMETHYLATION
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Summary:A mild, versatile and efficient method for the silver(I)-catalyzed oxidative decarboxylative gem-difluoromethylenation has been developed. The radical cascade reaction comprises the addition of an oxidatively generated difluoromethylene radical to the isonitrile functionality and subsequent homolytic aromatic substitution. It provides a novel and efficient access to the C-CF2 bond formation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c5cc09179a