Function of Caveolae in Ca2+ Entry and Ca2+‐Dependent Signal Transduction

The correct spatial and temporal control of Ca2+ signaling is essential for such cellular activities as fertilization, secretion, motility, and cell division. There has been a long‐standing interest in the role of caveolae in regulating intracellular Ca2+ concentration. In this review we provide an...

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Bibliographic Details
Published inTraffic (Copenhagen, Denmark) Vol. 4; no. 11; pp. 717 - 723
Main Authors Isshiki, Masashi, Anderson, Richard G. W.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.11.2003
Subjects
Animals
Ca2+ entry
Ca2+ waves
Calcium - metabolism
Calcium Channels - metabolism
Calcium Signaling - physiology
capacitative
caveolae
Caveolae - metabolism
caveolin
Cell Membrane - metabolism
eNOS
Inositol 1,4,5-Trisphosphate - metabolism
Inositol 1,4,5-Trisphosphate Receptors
Muscle, Skeletal - metabolism
Receptors, Cytoplasmic and Nuclear - metabolism
signal transduction
store‐operated Ca2+ entry
Time Factors
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Summary:The correct spatial and temporal control of Ca2+ signaling is essential for such cellular activities as fertilization, secretion, motility, and cell division. There has been a long‐standing interest in the role of caveolae in regulating intracellular Ca2+ concentration. In this review we provide an updated view of how caveolae may regulate both Ca2+ entry into cells and Ca2+‐dependent signal transduction
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1398-9219
1600-0854
DOI:10.1034/j.1600-0854.2003.00130.x