Distribution of HER2(V655) genotypes in breast cancer cases and controls in the United States

The minor variant frequency of a HER2 polymorphism (HER2(V655)) has been determined for 471 United States women enrolled in a multiracial case-control study. Allelic frequencies varied significantly by race. Genotypic distributions showed no excess breast cancer risk associated with inheritance of H...

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Bibliographic Details
Published inCancer letters Vol. 173; no. 1; pp. 37 - 41
Main Authors Keshava, C, McCanlies, E C, Keshava, N, Wolff, M S, Weston, A
Format Journal Article
LanguageEnglish
Published Ireland 08.11.2001
Subjects
Breast Neoplasms - ethnology
Breast Neoplasms - genetics
Female
Gene Frequency
Genes, erbB-2
Genotype
Humans
Polymorphism, Genetic
United States - ethnology
United States
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Summary:The minor variant frequency of a HER2 polymorphism (HER2(V655)) has been determined for 471 United States women enrolled in a multiracial case-control study. Allelic frequencies varied significantly by race. Genotypic distributions showed no excess breast cancer risk associated with inheritance of HER2(V655) either as carriers (OR=1.2, 95% CI=0.8-1.9), heterozygotes (OR=1.2, 95% CI=0.8-1.9), or homozygotes (OR=1.4, 95% CI=0.4-4.2). Nor was there a significant association when each racial group was considered separately. The current study suggests the HER2(V655) allele is not a breast cancer risk factor for Caucasians, African-Americans, or Latinas.
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ISSN:0304-3835
1872-7980
DOI:10.1016/s0304-3835(01)00671-1