Lactoferrin concentration in milk of bovine clinical mastitis

• Published in: Veterinary research communications Vol. 23; no. 7; pp. 391 - 398
• Main Authors: Kawai, K, Hagiwara, S, Anri, A, Nagahata, H
• Format: Journal Article
• Language: English
• Published: Netherlands Springer Nature B.V 01.11.1999
• Subjects: Animals; Cattle; Escherichia coli - isolation & purification; Escherichia coli - pathogenicity; Escherichia coli Infections - immunology; Escherichia coli Infections - veterinary; Female; Immunodiffusion - veterinary; Lactoferrin - analysis; Mastitis, Bovine - immunology; Milk - chemistry; Milk - immunology; Milk - microbiology; Mycoplasma - isolation & purification; Mycoplasma - pathogenicity; Mycoplasma Infections - immunology; Mycoplasma Infections - veterinary; Staphylococcal Infections - immunology; Staphylococcal Infections - veterinary; Staphylococcus aureus - isolation & purification; Staphylococcus aureus - pathogenicity; Streptococcal Infections - immunology; Streptococcal Infections - veterinary; Streptococcus - isolation & purification; Streptococcus - pathogenicity
• ISSN: 0165-7380; 1573-7446
• DOI: 10.1023/a:1006347423426

The lactoferrin (LF) concentration in the milk from dairy cows with clinical mastitis was determined to evaluate the relationship between the LF concentration (LFC) in milk and the non-specific defensive capability of the udder. The mean LFC in 368 milk samples from 319 cows with clinical mastitis was significantly higher (p < 0.01) than that of normal cows. The mean LFC in milk from quarters infected with Mycoplasma bovis or Staphylococcus aureus was significantly higher (p < 0.05) than that of quarters infected with coagulase-negative staphylococci (CNS). In Escherichia coli mastitis, the level of LFC in milk from cows with peracute mastitis was significantly lower (p < 0.01) than that from cows with acute mastitis. In cases of mastitis due to E. coli, the mean LFC in milk from cows that needed more than 10 days to recover from the mastitis or were not cured was significantly lower (p < 0.05) than that for cows which took less than 10 days to be cured. The mean LFC in milk from cows with peracute E. coli mastitis was significantly lower (p < 0.05) than that for cows with mastitis associated with environmental streptococci or CNS, although these low LF levels were somewhat increased after 46 h from the occurrence of mastitis. These results suggest that the decreased levels of LF in peracute E. coli mastitis may be associated with the progress of inflammation in the early phase of mastitis.