CLINICAL EXPERIENCE OF CINOXACIN ON URINARY TRACT INFECTIONS

• Published in: CHEMOTHERAPY Vol. 28; no. Supplement4; pp. 318 - 326
• Main Author: MIZUNOE, YOSHIMITSU
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 01.01.1980
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.28.Supplement4_318

1. Cinoxacin was administered to 45 patients with urinary tract infections diagnosed from October 1978 to June 1979 at the Department of Urology of Kyushu University and of 5 relevant hospitals. 2. Of 45 cases with urinary tract infections, 38 cases recieved 800mg of the compound a day in 2 divided doses and 7 cases recieved 800mg a day in 4 divided doses. Of all cases, 1 case was given for 2 days, 23 cases for 3 days, 2 cases for 4 days, 17 cases for 5 days and 2 cases for 7 days. 3. Clinical efficacy was proved at 94.1% in 34 cases with acute simple urinary tract infections and 60.0% in 11 cases with chronic complicated urinary tract infections according to the judgment of the doctor in charge of this study. 4. Overall clinical of ficacy was proved at 100% in 20 cases with acute simple cystitis according to criteria for evaluation of efficacy of antimicrobial agents on acute simple U. T. I. On the other hand, 60.0% of overall clinical efficacy was obtained in 5 cases with chronic complicated urinary tract infections according to criteria for evaluation of efficacy of antimicrobial agents on chronic complicated U. T. I. in Japan. 5. Bacteriologically, bacteria vanished in 33 strains of 38. 6. Side effects were seen in 3 cases with a stomatitis, a general itching and a nettle rash. Anyway, those symptoms disappeared immediately after discontinuation of the administration without any special treatment. No abnormality was observed on laboratory findings.