BASIC AND CLINICAL STUDIES ON CEFOTAXIME IN UROLOGICAL INFECTIONS

• Published in: CHEMOTHERAPY Vol. 28; no. Supplement1; pp. 734 - 755
• Main Authors: SUZUKI, KEIZO, NAGAKUBO, ICHIRO, MORIGUCHI, RYUICHIRO, MITSUI, HISAO, NAIDE, YORIO, FUJITA, TAMIO, OKISHIO, NORIHIKO, ASANO, HARUYOSHI, YAMAKOSHI, TSUYOSHI
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 01.01.1980
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.28.Supplement1_734

The antimicrobial activity of cefotaxime in vitro was investigated against 111 strains of clinically isolated gram-negative bacilli with cefamandole used as the control. Cefotaxime showed higher activities than cefamandole did on all tested strains, among which, against E. coli, K. pneumoniae, P. mirabilis and P. rettgeri remarkably greater activity, that is approximately 4 or 5 times more than cefamandole was observed. The levels in the blood and urine and urinary recovery were studied after one shot i. v. administration of 500 mg cefotaxime in two healthy volunteers. The peak blood level was obtained at 18.15μg/ml 15 minutes after injection, then diminished rapidly and trace was determined 4 hours later. Recovery in the urine up to 6 hours was 55.7%. The diffusion into human prostatic fluids was determined in seven prostatitis patients. The average level of cefotaxime were found 1.0μg/ml one hour after dosing and the ratio between the fluid and serum concentration was 0.12. Cefotaxime was given clinically to 43 cases totally, in which complicated urinary tract infection was included 33 cases. The rate of sufficient efficacy was 69.7% by the criteria of UTI committee, by doctors' judgement, the result yielded excellent efficacy in 78.8%. All 4 cases of acute simple UTI, and 3 cases of acute gonorrheal urethritis responded excellently ; one case of non-gonorrheal urethritis resulted in fair response. No serious side effects were observed on laboratory values of liver, renal functions except in 2 cases with slight abnormality of liver function, and 3 cases in renal function. The values returned to -normal levels after discontinuation of the treatment in all these cases.