Hepatitis E Virus (HEV) Infection in Anti-HEV Immunoglobulin G-Carrying Patients After Successful Hepatitis C Virus Treatment: Reactivation or Reinfection?

Although hepatitis E virus (HEV) is regarded as a self-limiting infection and anti-HEV antibodies seem to protect against reinfection, its pathogenesis is not well established. We describe 2 cases of acute symptomatic HEV infection after hepatitis C therapy in patients carrying anti-HEV immunoglobul...

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Published inClinical infectious diseases Vol. 64; no. 7; pp. 964 - 966
Main Authors Rivero-Juarez, Antonio, Frias, Mario, Lopez-Lopez, Pedro, de Los Angeles Risalde, María, Brieva, Teresa, Machuca, Isabel, Camacho, Angela, Martinez-Peinado, Antonio, Gomez-Villamandos, Jose Carlos, Rivero, Antonio
Format Journal Article
LanguageEnglish
Published United States Oxford University Press 01.04.2017
Subjects
Aged
Antiretroviral Therapy, Highly Active
Antiviral Agents - therapeutic use
BRIEF REPORTS
Coinfection
Female
Hepatitis
Hepatitis Antibodies - blood
Hepatitis Antibodies - immunology
Hepatitis C
Hepatitis C - drug therapy
Hepatitis C - virology
Hepatitis C virus
Hepatitis E - diagnosis
Hepatitis E - immunology
Hepatitis E - virology
Hepatitis E virus
Hepatitis E virus - immunology
Hepeviridae
HIV Infections - diagnosis
HIV Infections - drug therapy
HIV Infections - virology
Humans
Immunoglobulin G - blood
Immunoglobulin G - immunology
Immunoglobulin M - blood
Immunoglobulin M - immunology
Immunoglobulins
Male
Medical treatment
Middle Aged
Pathogenesis
Viral Load
Virus Activation
hepatitis E
reactivation
reinfection
HIV
hepatitis C
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Summary:Although hepatitis E virus (HEV) is regarded as a self-limiting infection and anti-HEV antibodies seem to protect against reinfection, its pathogenesis is not well established. We describe 2 cases of acute symptomatic HEV infection after hepatitis C therapy in patients carrying anti-HEV immunoglobulin G antibodies, raising 2 major questions: reactivation or reinfection?
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
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ObjectType-Feature-2
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/cix004