Structure and function of fibrinogen inferred from hereditary dysfibrinogens

The structure-function relationships of human fibrinogen and their clinical implications are discussed on the basis of data provided by biochemical and electron microscopic analyses of normal and abnormal fibrinogen and by recent crystallographic studies on certain functional domains and segments of...

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Bibliographic Details
Published inInternational journal of hematology Vol. 72; no. 4; p. 436
Main Author Matsuda, M
Format Journal Article
LanguageEnglish
Published Japan 01.12.2000
Subjects
Binding Sites
Family Health
Fibrin - genetics
Fibrin - metabolism
Fibrin - ultrastructure
Fibrinogen - chemistry
Fibrinogen - genetics
Fibrinogen - physiology
Fibrinogens, Abnormal - chemistry
Fibrinogens, Abnormal - genetics
Fibrinogens, Abnormal - physiology
Humans
Structure-Activity Relationship
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Summary:The structure-function relationships of human fibrinogen and their clinical implications are discussed on the basis of data provided by biochemical and electron microscopic analyses of normal and abnormal fibrinogen and by recent crystallographic studies on certain functional domains and segments of normal fibrinogen. Particularly, ultrastructure studies of individual fibrinogen molecules and fibrin networks of structurally elucidated dysfibrinogens enable us to understand the structure-function relationships of these dysfibrinogens more clearly than ever. Electron micrographs of some representative dysfibrinogen molecules are provided.
ISSN:0925-5710