Differential expression of insulin-like growth factor 1 in human primary liver cancer

• Published in: Fukuoka igaku zasshi = Hukuoka acta medica Vol. 104; no. 10; p. 334
• Main Authors: Ikeda, Yasuharu, Kajiyama, Kiyoshi, Yamashita, Yo-Ichi, Ikegami, Toru, Uchiyama, Hideaki, Soejima, Yuji, Kawanaka, Hirofumi, Ikeda, Tetsuo, Morita, Masaru, Oki, Eiji, Saeki, Hiroshi, Suehiro, Taketoshi, Mimori, Kohshi, Sugimachi, Keishi, Shirabe, Ken, Maehara, Yoshihiko
• Format: Journal Article
• Language: English
• Published: Japan 25.10.2013
• Subjects: Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - pathology; Female; Gene Expression Regulation, Neoplastic - genetics; Gene Expression Regulation, Neoplastic - physiology; Humans; Insulin-Like Growth Factor I - genetics; Insulin-Like Growth Factor I - metabolism; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Male; Neoplasm Invasiveness - genetics; Portal Vein - pathology; Vascular Neoplasms - pathology
• ISSN: 0016-254X

Insulin-like Growth Factor 1 (IGF-1) antigen was immunohistochemically examined in 28 patients of the primary hepatocellular carcinoma with hepatectomy. IGF-1 was expressed in 93% (26/28) of the primary lesion and 100% (28/28) of the normal liver. Compared with expression in normal liver, decreased expressions in primary lesions were noted in 36% (10/28) for IGF-1. Histological examination revealed that there were significant correlations between patients with decreased expressions of IGF-1 in primary lesions and poor differentiated hepatocellular carcinoma, and portal vein infiltration. These results indicate that expression of IGF-1 has the relationship with the differentiation in human primary hepatocellular carcinoma.