INDUCTION OF PULMONARY TUMORS IN MICE WITH ISONICOTINIC ACID HYDRAZID

Isonicotinic acid hydrazide (INH), a tuberculostatic or tuberculocitic compound of wide use, induced pulmonary tumors when it was fed to mice with diet. Under the usual conditions of our experiments multiple pulmonary tumors were engendered in high proportions of animals surviving 7 months. Two mont...

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Published inGANN Japanese Journal of Cancer Research Vol. 51; no. 1; pp. 83 - 89_2
Main Authors MORI, KAZUO, YASUNO, AKIRA, MATSUMOTO, KATSUHIKO
Format Journal Article
LanguageEnglish
Published Japan The Japanese Cancer Association 01.03.1960
Subjects
Animals
Isoniazid - toxicity
Isonicotinic Acids
Lung Neoplasms
Mice
Neoplasms, Experimental
ISONIAZID/toxicology
LUNG NEOPLASMS/experimental
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Summary:Isonicotinic acid hydrazide (INH), a tuberculostatic or tuberculocitic compound of wide use, induced pulmonary tumors when it was fed to mice with diet. Under the usual conditions of our experiments multiple pulmonary tumors were engendered in high proportions of animals surviving 7 months. Two months of feeding of INH are sufficient to induce pulmonary tumors in 60 per cent of animals whithin 7 months. The pulmonary tumors induced by INH feeding are apparently initiated by the hyperplasia of the alveolar epithelium and could be classified as adenomas identical in appearance with the spontaneous pulmonary tumors that occur in the strain. A few substances related to INH, namely pyrazinamide, Neoiscotin, and semicarbazide, also produce pulmonary tumors. All these compounds have carbamyl groups in their chemical structures.
ISSN:0016-450X
DOI:10.20772/cancersci1959.51.1_83