Influences of Ovariectomy and Continuous Replacement of 17β-Estradiol on the Tail Skin Temperature and Behavior in the Forced Swimming Test in Rats

• Published in: The Japanese Journal of Pharmacology Vol. 73; no. 1; pp. 93 - 96
• Main Authors: Okada, Mikiko, Hayashi, Naoyuki, Kometani, Motohiko, Nakao, Kenzo, Inukai, Toshiya
• Format: Journal Article
• Language: English
• Published: The Japanese Pharmacological Society 01.01.1997
• Subjects: Forced swimming test; Ovariectomy; Tail skin temperature
• ISSN: 0021-5198; 1347-3506
• DOI: 10.1254/jjp.73.93

The effect of ovariectomy and continuous subcutaneous replacement of 17β-estradiol was examined in female Wistar rats. Tail skin temperature significantly increased in ovariectomized rats 6 days after ovariectomy, and the elevated level was sustained until 21 days after ovariectomy. 17β-Estradiol at doses of 0.3 and 1.0 μg/body/day suppressed the increases in tail skin temperature. In the forced swimming test, the ovariectomized control rats showed significantly prolonged immobility time in comparison with sham-ovariectomized rats 14 days after ovariectomy. The duration of immobility of ovariectomized rats treated with 17β-estradiol (0.3, 1.0, 3.0 μg/body/day)or maprotiline (0.6 mg/body/day)was significantly shorter than that of ovariectomized control rats.