Implications of Developmental Gene Regulatory Networks Inside and Outside Developmental Biology

The insight that the genomic control of developmental process is encoded in the form of gene regulatory networks has profound impacts on many areas of modern bioscience. Most importantly, it affects developmental biology itself, as it means that a causal understanding of development requires knowled...

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Bibliographic Details
Published inCurrent topics in developmental biology Vol. 117; pp. 237 - 251
Main Authors Peter, Isabelle S, Davidson, Eric H
Format Journal Article
LanguageEnglish
Published United States 01.01.2016
Subjects
Animals
Biological Evolution
Developmental Biology
Gene Expression Regulation, Developmental
Gene Regulatory Networks
Genome
Humans
Developmental process
Gene regulatory networks
Genomic information
Genomics
Evolution
Transcriptional control
cis-Regulatory module
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Summary:The insight that the genomic control of developmental process is encoded in the form of gene regulatory networks has profound impacts on many areas of modern bioscience. Most importantly, it affects developmental biology itself, as it means that a causal understanding of development requires knowledge of the architecture of regulatory network interactions. Furthermore, it follows that functional changes in developmental gene regulatory networks have to be considered as a primary mechanism for evolutionary process. We here discuss some of the recent advances in gene regulatory network biology and how they have affected our current understanding of development, evolution, and regulatory genomics.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1557-8933
DOI:10.1016/bs.ctdb.2015.12.014