Quantitative analysis of cystoid macular edema using scanning laser ophthalmoscope in modified dark-field imaging

• Published in: Retina (Philadelphia, Pa.) Vol. 32; no. 9; p. 1892
• Main Authors: Katome, Takashi, Mitamura, Yoshinori, Nagasawa, Toshihiko, Eguchi, Hiroshi, Naito, Takeshi
• Format: Journal Article
• Language: English
• Published: United States 01.10.2012
• Subjects: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors - therapeutic use; Antibodies, Monoclonal, Humanized - therapeutic use; Bevacizumab; Combined Modality Therapy; Fluorescein Angiography; Glucocorticoids - therapeutic use; Humans; Laser Coagulation; Lasers; Macular Edema - diagnosis; Macular Edema - physiopathology; Macular Edema - therapy; Middle Aged; Ophthalmoscopes; Retina - physiopathology; Tomography, Optical Coherence; Triamcinolone Acetonide - therapeutic use; Visual Acuity - physiology
• ISSN: 1539-2864
• DOI: 10.1097/iae.0b013e3182497141

To quantitatively analyze cystoid macular edema (CME) using scanning laser ophthalmoscope in the modified dark-field imaging. We studied 37 eyes with CME associated with different diseases before and after treatment. The CME area was measured with the modified dark-field imaging and fluorescein angiography. The best-corrected visual acuity, mean deviation and macular sensitivity measured by Humphrey automated perimetry, and foveal thickness and macular volume determined by optical coherence tomography were investigated. The CME area could be clearly outlined in 50% with the fluorescein angiography and in 100% with the modified dark-field imaging (P < 0.0001). The CME area calculated using the modified dark-field imaging was significantly correlated with that using the fluorescein angiography (P = 0.0001). Before treatment, the CME area calculated using the modified dark-field imaging was significantly correlated with only the macular volume (P = 0.0230). Three months after treatment, decrease in the CME area was significantly correlated with improvement in the best-corrected visual acuity, mean deviation, macular sensitivity, foveal thickness, and macular volume (P < 0.05 for all). Our findings indicate that scanning laser ophthalmoscope in the modified dark-field imaging can measure the CME area and is useful in analyzing CME quantitatively. The findings can also be used to evaluate the effectiveness of treatment.