S100 family proteins in inflammation and beyond

• Published in: Advances in clinical chemistry Vol. 98; p. 173
• Main Authors: Sreejit, Gopalkrishna, Flynn, Michelle C, Patil, Mallikarjun, Krishnamurthy, Prasanna, Murphy, Andrew J, Nagareddy, Prabhakara R
• Format: Journal Article
• Language: English
• Published: United States 2020
• Subjects: Animals; Anti-Inflammatory Agents - therapeutic use; Biomarkers - metabolism; Humans; Inflammation - drug therapy; Inflammation - metabolism; S100 Proteins - metabolism; Myocardial infarction; Obesity; Psoriasis; S100 proteins; Cardiomyocytes; Inflammatory response; Inflammasome; Ca(2+) signaling; EF-hand motif; Phagocytes; Inhibitors; Sarcoplasmic reticulum; WBC; Diabetes; Cancer

The S100 family proteins possess a variety of intracellular and extracellular functions. They interact with multiple receptors and signal transducers to regulate pathways that govern inflammation, cell differentiation, proliferation, energy metabolism, apoptosis, calcium homeostasis, cell cytoskelet...