S100 family proteins in inflammation and beyond

The S100 family proteins possess a variety of intracellular and extracellular functions. They interact with multiple receptors and signal transducers to regulate pathways that govern inflammation, cell differentiation, proliferation, energy metabolism, apoptosis, calcium homeostasis, cell cytoskelet...

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Published inAdvances in clinical chemistry Vol. 98; p. 173
Main Authors Sreejit, Gopalkrishna, Flynn, Michelle C, Patil, Mallikarjun, Krishnamurthy, Prasanna, Murphy, Andrew J, Nagareddy, Prabhakara R
Format Journal Article
LanguageEnglish
Published United States 2020
Subjects
Animals
Anti-Inflammatory Agents - therapeutic use
Biomarkers - metabolism
Humans
Inflammation - drug therapy
Inflammation - metabolism
S100 Proteins - metabolism
Myocardial infarction
Obesity
Psoriasis
S100 proteins
Cardiomyocytes
Inflammatory response
Inflammasome
Ca(2+) signaling
EF-hand motif
Phagocytes
Inhibitors
Sarcoplasmic reticulum
WBC
Diabetes
Cancer
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Summary:The S100 family proteins possess a variety of intracellular and extracellular functions. They interact with multiple receptors and signal transducers to regulate pathways that govern inflammation, cell differentiation, proliferation, energy metabolism, apoptosis, calcium homeostasis, cell cytoskeleton and microbial resistance. S100 proteins are also emerging as novel diagnostic markers for identifying and monitoring various diseases. Strategies aimed at targeting S100-mediated signaling pathways hold a great potential in developing novel therapeutics for multiple diseases. In this chapter, we aim to summarize the current knowledge about the role of S100 family proteins in health and disease with a major focus on their role in inflammatory conditions.
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ISSN:2162-9471
2162-9471
DOI:10.1016/bs.acc.2020.02.006