薬剤送達後の熱変性血管壁からの薬剤放出

• Published in: Transactions of Japanese Society for Medical and Biological Engineering Vol. 54Annual; no. 28AM-Abstract; p. S318
• Main Authors: 本間, 理恵, 島崎, 夏美, 荒井, 恒憲, 小川, 恵美悠
• Format: Journal Article
• Language: Japanese
• Published: 公益社団法人 日本生体医工学会 2016; Japanese Society for Medical and Biological Engineering
• ISSN: 1347-443X; 1881-4379
• DOI: 10.11239/jsmbe.54Annual.S318

We studied agent washout by blood flow from thermal denatured vascular wall to keep sufficient delivered agent quantity in vascular wall on chronic phase to avoid the restenosis occurrence. We measured the changing of the Rhodamine B fluorescence intensity in the denatured vascular wall during the washout by the constructed closed cycled circulation system with saline to match shear stress to the vascular wall surface. We calculated diffusion coefficient of the agent between the vascular surface and the circulation system during the washout. The diffusion coefficient of the delivered agent with 70°C heating tended to decreased compared with 37°C heating. There were no significantly increased of the diffusion coefficient with increasing of the shear stress to vascular wall. We prospected that the heating to the vascular wall might make the vascular hydrophobic region increasing and enhance the retention of the agent in the vascular wall.