Computational modeling on intracranial fluid dynamics: cerebrospinal and interstitial fluids

• Published in: Transactions of Japanese Society for Medical and Biological Engineering Vol. Annual59; no. Abstract; p. 187
• Main Authors: Otani, Tomohiro, Ilik, Selin Yavuz, Yamada, Shigeki, Watanabe, Yoshiyuki, Wada, Shigeo, Takeishi, Naoki, Maeda, Shusaku
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society for Medical and Biological Engineering 2021; 公益社団法人 日本生体医工学会
• ISSN: 1347-443X; 1881-4379
• DOI: 10.11239/jsmbe.Annual59.187

The intracranial region is filled in various kinds of fluids such as blood, cerebrospinal fluid, and interstitial fluid. It is commonly known that these fluids always satisfy a mechanical equilibrium state, however little is known about underlying mechanism to maintain this equilibrium state as a homeostasis. Recent experimental studies have revealed details of intracranial fluid circulation with exchanges among fluids. These findings potentially update conventional understanding of the physiological mechanism of the intracranial fluid circulation. As a tool to integrate and interpret these recent findings from mechanical viewpoint, we have begun to develop a computational mechanical model of the intracranial fluid circulation. This presentation introduces perspectives of the computational model to be developed and a personalized computational framework of the cerebrospinal fluid flow, as the first step.