Studies on Positive Inotropic Agents. I. Synthesis of 3, 4-Dihydro-6-[4-(3, 4-dimethoxybenzoyl)-1-piperazinyl]-2 (1H)-quinolinone and Related Compounds

Many (1-piperazinyl)-2 (1H)-quinolinone derivatives were synthesized and examined for positive inotropic activities on the canine heart. Among them, 3, 4-dihydro-6-[4-(3, 4-dimethoxybenzoyl)-1-piperazinyl]-2 (1H)-quinolinone (XVIIb-1) was found to have a very potent activity.

Saved in:
Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 32; no. 6; pp. 2100 - 2110
Main Authors TOMINAGA, MICHIAKI, YO, EIYU, OGAWA, HIDENORI, YAMASHITA, SHUJI, YABUUCHI, YOUICHI, NAKAGAWA, KAZUYUKI
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 01.06.1984
Maruzen
Japan Science and Technology Agency
Subjects
Animals
biological activity
Cardiotonic Agents - chemical synthesis
Cardiotonic Agents - pharmacology
Chemical Phenomena
Chemistry
Dogs
Exact sciences and technology
Heart Rate - drug effects
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
In Vitro Techniques
Myocardial Contraction - drug effects
Organic chemistry
Preparations and properties
Quinolines - chemical synthesis
Quinolines - pharmacology
Cardiotonic agent
Nitrogen heterocycle
Six membered ring
Lactam
Bicyclic compound
Aromatic compound
Biological activity
Online AccessGet full text

Cover

More Information
Summary:Many (1-piperazinyl)-2 (1H)-quinolinone derivatives were synthesized and examined for positive inotropic activities on the canine heart. Among them, 3, 4-dihydro-6-[4-(3, 4-dimethoxybenzoyl)-1-piperazinyl]-2 (1H)-quinolinone (XVIIb-1) was found to have a very potent activity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.32.2100