CO-OPERATION BETWEEN MACROPHAGES AND A FACTOR FROM LYMPHOCYTES IN TUMOR LYSIS IN VITRO

Peritoneal cells from C3H/He mice immunized against syngeneic MM46 ascites tumor cells specifically lysed these tumor cells in vitro, while spleen cells or lymph node cells from immunized hosts were completely ineffective. The effector cells differed from lymphocytes in their morphological character...

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Published inGANN Japanese Journal of Cancer Research Vol. 66; no. 5; pp. 489 - 497
Main Authors YAMAZAKI, Masatoshi, SHINODA, Hirotaka, MIZUNO, Den'ichi
Format Journal Article
LanguageEnglish
Published Japan The Japanese Cancer Association 01.10.1975
Subjects
Animals
Antibodies, Anti-Idiotypic
Antigens, Neoplasm
Antilymphocyte Serum
C3H/He mouse
Cell-mediated cytolysis
Cytotoxicity Tests, Immunologic
Effector macrophage
Lymphocytes - immunology
Lymphocytic activating factor
Macrophages - immunology
Mice
Mice, Inbred C3H
MM46 mammary carcinoma
Neoplasms, Experimental - immunology
T-Lymphocytes - immunology
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Summary:Peritoneal cells from C3H/He mice immunized against syngeneic MM46 ascites tumor cells specifically lysed these tumor cells in vitro, while spleen cells or lymph node cells from immunized hosts were completely ineffective. The effector cells differed from lymphocytes in their morphological characteristics, property of adherence, phagocytic activity, and sensitivity to anti-θ serum. The cytolytic action of the peritoneal cells was not due to cytotoxic lymphocytes, but to macrophages. These macrophages lysed tumor cells in co-operation with a factor derived from immunoglobulin-bearing lymphocytes. Neither macrophages from immunized hosts nor the factor from lymphocytes alone had a cytolytic action on the target cells. Normal macrophages showed some cytolytic activity in the presence of the factor from lymphocytes.
ISSN:0016-450X
DOI:10.20772/cancersci1959.66.5_489