Suppression of TNFα expression induced by indole-3-acetic acid is not mediated by AhR activation in Caco-2 cells

ABSTRACT Indole-3-acetic acid (IAA) produced by intestinal bacteria from tryptophan in dietary proteins is considered to suppress the inflammatory response through aryl hydrocarbon receptor (AhR) activation. However, AhR activation was not involved in the downregulation of tumor necrosis factor α (T...

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Published inBioscience, biotechnology, and biochemistry Vol. 85; no. 4; pp. 902 - 906
Main Authors Chowdhury, Md Mazharul Islam, Kurata, Koichi, Yuasa, Kana, Koto, Yoshihito, Nishimura, Kohji, Shimizu, Hidehisa
Format Journal Article
LanguageEnglish
Published England Oxford University Press 24.03.2021
Subjects
tumor necrosis factor α
colorectal cancer
cytochrome P450 1A1
inflammation
aryl hydrocarbon receptor
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Summary:ABSTRACT Indole-3-acetic acid (IAA) produced by intestinal bacteria from tryptophan in dietary proteins is considered to suppress the inflammatory response through aryl hydrocarbon receptor (AhR) activation. However, AhR activation was not involved in the downregulation of tumor necrosis factor α (TNFα) expression induced by IAA in Caco-2 cells. The activation of unidentified IAA receptors might attenuate the inflammatory response to TNFα in colorectal cancer cells.
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ISSN:1347-6947
DOI:10.1093/bbb/zbaa101