Relapsing herpes simplex encephalitis resulting in Kluver-Bucy syndrome

Relapsing herpes simplex encephalitis (HSE) rarely occurs after acyclovir treatment. We treated a patient with relapsing HSE of the contralateral temporal lobe, resulting in Klüver-Bucy syndrome, after a full-dose acyclovir treatment. This case suggests that physicians should consider sudden behavio...

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Published inInternal medicine (Tokyo, 1992) Vol. 50; no. 7; pp. 763 - 766
Main Authors Ku, Bon D, Yoon, Sung Sang
Format Journal Article
LanguageEnglish
Published Japan 01.01.2011
Subjects
acyclovir
Acyclovir - therapeutic use
Adult
Antiviral Agents - therapeutic use
Brain - pathology
Brain - physiopathology
Dose-Response Relationship, Drug
Electroencephalography
Emotional behavior
Encephalitis
Encephalitis, Herpes Simplex - complications
Encephalitis, Herpes Simplex - drug therapy
Epilepsy
Herpes simplex
Humans
Kluver-Bucy syndrome
Kluver-Bucy Syndrome - diagnosis
Kluver-Bucy Syndrome - etiology
Magnetic Resonance Imaging
Male
Recurrence
Temporal lobe
Treatment Outcome
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Summary:Relapsing herpes simplex encephalitis (HSE) rarely occurs after acyclovir treatment. We treated a patient with relapsing HSE of the contralateral temporal lobe, resulting in Klüver-Bucy syndrome, after a full-dose acyclovir treatment. This case suggests that physicians should consider sudden behavioral and emotional changes after HSE treatment as a possible indication of relapsing HSE, as well as possible temporal lobe epilepsy, and the need to administer longer acyclovir treatment for select patients.
Bibliography:ObjectType-Case Study-3
SourceType-Scholarly Journals-1
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ISSN:1349-7235
1349-7235
DOI:10.2169/internalmedicine.50.4792