頭痛性疾患における臨床神経機能検査
近年急速に進歩している脳機能画像診断法，特にMRI を用いて行うfMRI（functional magnetic resonance imaging）やVBM（Voxel-based morphometry）は低侵襲で簡便に繰り返し行えることより，片頭痛や群発頭痛の病態について多くの新たな知見が報告されている．片頭痛については，fMRI，安静時fMRI，VBM より片頭痛発作周期に伴い，疼痛刺激に対する活性化部位や視床下部との結合能が変化し，体積も疼痛処理に関する部位を中心に発作期と発作間欠期で変化することが示されてきた．群発頭痛では，fMR とVBM を用いて視床下部の活性化と細胞密度の増加...
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| Published in | 日本臨床生理学会雑誌 Vol. 49; no. 3; pp. 113 - 123 |
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| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本臨床生理学会
01.08.2019
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0286-7052 2435-1695 |
| DOI | 10.34363/jocp.49.3_113 |
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| Abstract | 近年急速に進歩している脳機能画像診断法，特にMRI を用いて行うfMRI（functional magnetic resonance imaging）やVBM（Voxel-based morphometry）は低侵襲で簡便に繰り返し行えることより，片頭痛や群発頭痛の病態について多くの新たな知見が報告されている．片頭痛については，fMRI，安静時fMRI，VBM より片頭痛発作周期に伴い，疼痛刺激に対する活性化部位や視床下部との結合能が変化し，体積も疼痛処理に関する部位を中心に発作期と発作間欠期で変化することが示されてきた．群発頭痛では，fMR とVBM を用いて視床下部の活性化と細胞密度の増加，中脳との結合能の変化が示されている．これらのfMRI，VBM の研究から，片頭痛ならびに群発頭痛は構造的，機能結合的にダイナミックに変化する疾患であることが明らかになってきた． |
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| AbstractList | 「要約」近年急速に進歩している脳機能画像診断法, 特にMRIを用いて行うfMRI(functional magnetic resonance imaging)やVBM(Voxel-based morphometry)は低侵襲で簡便に繰り返し行えることより, 片頭痛や群発頭痛の病態について多くの新たな知見が報告されている. 片頭痛については, fMRI, 安静時fMRI, VBMより片頭痛発作周期に伴い, 疼痛刺激に対する活性化部位や視床下部との結合能が変化し, 体積も疼痛処理に関する部位を中心に発作期と発作間欠期で変化することが示されてきた. 群発頭痛では, fMRとVBMを用いて視床下部の活性化と細胞密度の増加, 中脳との結合能の変化が示されている. これらのfMRI, VBMの研究から, 片頭痛ならびに群発頭痛は構造的, 機能結合的にダイナミックに変化する疾患であることが明らかになってきた. 近年急速に進歩している脳機能画像診断法，特にMRI を用いて行うfMRI（functional magnetic resonance imaging）やVBM（Voxel-based morphometry）は低侵襲で簡便に繰り返し行えることより，片頭痛や群発頭痛の病態について多くの新たな知見が報告されている．片頭痛については，fMRI，安静時fMRI，VBM より片頭痛発作周期に伴い，疼痛刺激に対する活性化部位や視床下部との結合能が変化し，体積も疼痛処理に関する部位を中心に発作期と発作間欠期で変化することが示されてきた．群発頭痛では，fMR とVBM を用いて視床下部の活性化と細胞密度の増加，中脳との結合能の変化が示されている．これらのfMRI，VBM の研究から，片頭痛ならびに群発頭痛は構造的，機能結合的にダイナミックに変化する疾患であることが明らかになってきた． |
| Author | 今井, 昇 |
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| References | 6) Greicius MD, Krasnow B, Reiss AL, Menon V: Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci USA 2003, 100: 253‒258. 7) 根本清貴：Voxel-Based Morphometry の原理．BRAIN and NERVE 2017, 69: 505‒511 10) Antal A, Polania R, Saller K, Morawetz C, Schmidt-Samoa C, Baudewig J, Paulus W, Dechent P: Differential activation of the middle-temporal complex to visual stimulation in migraineurs. Cephalalgia 2011, 31: 338‒345 19) Hu W, Guo J, Chen N, Guo J, He L: A meta-analysis of voxel-based morphometric studies on migraine. Int J Clin Exp Med 2015, 8: 4311‒4319 4) 日本神経学会・日本頭痛学会 監：慢性頭痛の診療ガイドライン 2013．医学書院，2013，pp 75‒238 5) Ogawa S, Tank DW, Menon R, Ellermann JM, Kim SG, Merkle H, Ugurbil K: Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci USA 1992, 89: 5951‒5955 8) Cao Y, Welch KM, Aurora S, Vikingstad EM: Functional MRI-BOLD of visually triggered headache in patients with migraine. Arch Neurol 1999, 56: 548‒554 14) Schulte LH, Allers A, May A: The migraine generator revisited: continuous scanning of the migraine cycle over 30 days and three spontaneous attacks. Brain 2016, 139: 1987‒1993 20) Coppola G, Di Renzo A, Tinelli E, Iacovelli E, Lepre C, Di Lorenzo C, Di Lorenzo G, Di Lenola D, Parisi V, Serrao M, Pauri F, Fiermonte G, Bianco F, Pierelli F: Evidence for brain morphometric changes during the migraine cycle: a magnetic resonance-based morphometry study. Cephalalgia 2015, 35: 783‒791 17) Rocca MA, Ceccarelli A, Falini A, Colombo B, Tortorella P, Bernasconi L, Comi G, Scotti G, Filippi M: Brain gray matter changes in migraine patients with T2- visible lesions: a 3-T MRI study. Stroke 2006, 37: 1765‒1770 21) May A, Ashburner J, Büchel C, McGonigle DJ, Friston KJ, Frackowiak RS, Goadsby PJ: Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nat Med 1999, 5: 836‒838 11) Schwedt TJ, Chiang CC, Chong CD, Dodick DW: Functional MRI of migraine. Lancet Neurol 2015, 14: 81‒91 15) Imai N: Altered occipital pole connectivity in chronic versus episodic migraine: Whole brain region-of interest analysis of resting-state functional connectivity. Neurol Clin Neurosci 2018, 6: 173‒178 24) Naegel S, Holle D, Desmarattes N, Theysohn N, Diener HC, Katsarava Z, Obermann M: Cortical plasticity in episodic and chronic cluster headache. Neuroimage Clin 2014, 6: 415‒423 13) Coppola G, Di Renzo A, Tinelli E, Di Lorenzo C, Di Lorenzo G, Parisi V, Serrao M, Schoenen J, Pierelli F: Thalamo-cortical network activity during spontaneous migraine attacks. Neurology 2016, 87: 2154‒2160 2) 佐久間研司，竹島多賀夫，中島健二：片頭痛患者における体性感覚誘発高周波応答．臨床脳波 2006，48：603‒608 1) 日本頭痛学会・国際頭痛分類委員会 訳：国際頭痛分類第3 版．医学書院，2018 16) Matharu MS, Good CD, May A, Bahra A, Goadsby PJ: No change in the structure of the brain in migraine: a voxel-based morphometric study. Eur J Neurol 2003, 10: 53‒57 22) Morelli N, Pesaresi I, Cafforio G, Maluccio MR, Gori S, Di Salle F, Murri L: Functional magnetic resonance imaging in episodic cluster headache. J Headache Pain 2009, 10: 11‒14 23) Absinta M, Rocca MA, Colombo B, Falini A, Comi G, Filippi M: Selective decreased grey matter volume of the pain-matrix network in cluster headache. Cephalalgia 2012, 32: 109‒115 18) Dai Z, Zhong J, Xiao P, Zhu Y, Chen F, Pan P, Shi H: Gray matter correlates of migraine and gender effect: A meta-analysis of voxel-based morphometry studies. Neuroscience 2015, 299: 88‒96 3) 柴田興一：頭痛性疾患の神経生理学的研究．日本臨床 2017，75：866‒870 9) Borsook D, Burstein R, Moulton E, Becerra L: Functional imaging of the trigeminal system: applications to migraine pathophysiology. Headache 2006, 46 (Suppl 1): S32‒38 25) Ferraro S, Nigri A, Bruzzone MG, Brivio L, Proietti Cecchini A, Verri M, Chiapparini L, Leone M: Defective functional connectivity between posterior hypothalamus and regions of the diencephalic-mesencephalic junction in chronic cluster headache. Cephalalgia 2018, 38: 1910‒1918 12) Mainero C, Boshyan J, Hadjikhani N: Altered functional magnetic resonance imaging resting-state connectivity in periaqueductal gray network in migraine. Ann Neurol 2011, 70: 838‒845 |
| References_xml | – reference: 21) May A, Ashburner J, Büchel C, McGonigle DJ, Friston KJ, Frackowiak RS, Goadsby PJ: Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nat Med 1999, 5: 836‒838 – reference: 24) Naegel S, Holle D, Desmarattes N, Theysohn N, Diener HC, Katsarava Z, Obermann M: Cortical plasticity in episodic and chronic cluster headache. Neuroimage Clin 2014, 6: 415‒423 – reference: 14) Schulte LH, Allers A, May A: The migraine generator revisited: continuous scanning of the migraine cycle over 30 days and three spontaneous attacks. Brain 2016, 139: 1987‒1993 – reference: 13) Coppola G, Di Renzo A, Tinelli E, Di Lorenzo C, Di Lorenzo G, Parisi V, Serrao M, Schoenen J, Pierelli F: Thalamo-cortical network activity during spontaneous migraine attacks. Neurology 2016, 87: 2154‒2160 – reference: 9) Borsook D, Burstein R, Moulton E, Becerra L: Functional imaging of the trigeminal system: applications to migraine pathophysiology. Headache 2006, 46 (Suppl 1): S32‒38 – reference: 20) Coppola G, Di Renzo A, Tinelli E, Iacovelli E, Lepre C, Di Lorenzo C, Di Lorenzo G, Di Lenola D, Parisi V, Serrao M, Pauri F, Fiermonte G, Bianco F, Pierelli F: Evidence for brain morphometric changes during the migraine cycle: a magnetic resonance-based morphometry study. Cephalalgia 2015, 35: 783‒791 – reference: 15) Imai N: Altered occipital pole connectivity in chronic versus episodic migraine: Whole brain region-of interest analysis of resting-state functional connectivity. Neurol Clin Neurosci 2018, 6: 173‒178 – reference: 1) 日本頭痛学会・国際頭痛分類委員会 訳：国際頭痛分類第3 版．医学書院，2018 – reference: 2) 佐久間研司，竹島多賀夫，中島健二：片頭痛患者における体性感覚誘発高周波応答．臨床脳波 2006，48：603‒608 – reference: 23) Absinta M, Rocca MA, Colombo B, Falini A, Comi G, Filippi M: Selective decreased grey matter volume of the pain-matrix network in cluster headache. Cephalalgia 2012, 32: 109‒115 – reference: 7) 根本清貴：Voxel-Based Morphometry の原理．BRAIN and NERVE 2017, 69: 505‒511 – reference: 19) Hu W, Guo J, Chen N, Guo J, He L: A meta-analysis of voxel-based morphometric studies on migraine. Int J Clin Exp Med 2015, 8: 4311‒4319 – reference: 3) 柴田興一：頭痛性疾患の神経生理学的研究．日本臨床 2017，75：866‒870 – reference: 25) Ferraro S, Nigri A, Bruzzone MG, Brivio L, Proietti Cecchini A, Verri M, Chiapparini L, Leone M: Defective functional connectivity between posterior hypothalamus and regions of the diencephalic-mesencephalic junction in chronic cluster headache. Cephalalgia 2018, 38: 1910‒1918 – reference: 16) Matharu MS, Good CD, May A, Bahra A, Goadsby PJ: No change in the structure of the brain in migraine: a voxel-based morphometric study. Eur J Neurol 2003, 10: 53‒57 – reference: 10) Antal A, Polania R, Saller K, Morawetz C, Schmidt-Samoa C, Baudewig J, Paulus W, Dechent P: Differential activation of the middle-temporal complex to visual stimulation in migraineurs. Cephalalgia 2011, 31: 338‒345 – reference: 8) Cao Y, Welch KM, Aurora S, Vikingstad EM: Functional MRI-BOLD of visually triggered headache in patients with migraine. Arch Neurol 1999, 56: 548‒554 – reference: 17) Rocca MA, Ceccarelli A, Falini A, Colombo B, Tortorella P, Bernasconi L, Comi G, Scotti G, Filippi M: Brain gray matter changes in migraine patients with T2- visible lesions: a 3-T MRI study. Stroke 2006, 37: 1765‒1770 – reference: 4) 日本神経学会・日本頭痛学会 監：慢性頭痛の診療ガイドライン 2013．医学書院，2013，pp 75‒238 – reference: 6) Greicius MD, Krasnow B, Reiss AL, Menon V: Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci USA 2003, 100: 253‒258. – reference: 12) Mainero C, Boshyan J, Hadjikhani N: Altered functional magnetic resonance imaging resting-state connectivity in periaqueductal gray network in migraine. Ann Neurol 2011, 70: 838‒845 – reference: 22) Morelli N, Pesaresi I, Cafforio G, Maluccio MR, Gori S, Di Salle F, Murri L: Functional magnetic resonance imaging in episodic cluster headache. J Headache Pain 2009, 10: 11‒14 – reference: 11) Schwedt TJ, Chiang CC, Chong CD, Dodick DW: Functional MRI of migraine. Lancet Neurol 2015, 14: 81‒91 – reference: 18) Dai Z, Zhong J, Xiao P, Zhu Y, Chen F, Pan P, Shi H: Gray matter correlates of migraine and gender effect: A meta-analysis of voxel-based morphometry studies. Neuroscience 2015, 299: 88‒96 – reference: 5) Ogawa S, Tank DW, Menon R, Ellermann JM, Kim SG, Merkle H, Ugurbil K: Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci USA 1992, 89: 5951‒5955 |
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| Snippet | 近年急速に進歩している脳機能画像診断法，特にMRI を用いて行うfMRI（functional magnetic resonance imaging）やVBM（Voxel-based... 「要約」近年急速に進歩している脳機能画像診断法, 特にMRIを用いて行うfMRI(functional magnetic resonance imaging)やVBM(Voxel-based morphometry)は低侵襲で簡便に繰り返し行えることより,... |
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| SubjectTerms | functional MRI Voxel-based morphometry 片頭痛 疼痛処理 群発頭痛 |
| Title | 頭痛性疾患における臨床神経機能検査 |
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