腎臓移植におけるエピトープミスマッチ解析の意義について
「I. はじめに」多くの要因が腎移植患者の長期生存に影響を及ぼしているが, 中でもヒト白血球抗原(Human Leukocyte Antigen: HLA)は特に重要である. HLAタイピング技術は進化し, 3次元の構成要素をより正確に決定可能になった. そして, HLA抗体検査の最新技術が普及し, リスク予測も可能になりつつある. しかしながら, 拒絶反応発症原因や移植腎喪失に抗体が関与していることは変わらない. これは, 主要組織適合遺伝子複合体(Major Histocompatibility Complex: MHC)が拒絶反応に深く関与しており, HLAミスマッチ数や種類が細胞性と抗...
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| Published in | 移植 Vol. 56; no. 3; pp. 293 - 303 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Japanese |
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一般社団法人 日本移植学会
2021
日本移植学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0578-7947 2188-0034 |
| DOI | 10.11386/jst.56.3_293 |
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| Abstract | 「I. はじめに」多くの要因が腎移植患者の長期生存に影響を及ぼしているが, 中でもヒト白血球抗原(Human Leukocyte Antigen: HLA)は特に重要である. HLAタイピング技術は進化し, 3次元の構成要素をより正確に決定可能になった. そして, HLA抗体検査の最新技術が普及し, リスク予測も可能になりつつある. しかしながら, 拒絶反応発症原因や移植腎喪失に抗体が関与していることは変わらない. これは, 主要組織適合遺伝子複合体(Major Histocompatibility Complex: MHC)が拒絶反応に深く関与しており, HLAミスマッチ数や種類が細胞性と抗体関連拒絶反応の両方を引き起こすことを示唆している. HLA抗体は, 術前に検出されるドナー特異的HLA抗体(Donor Specific Antibody: DSA)も重要であるが, 移植後に検出されるde novo DSA(dnDSA)も重要とされ, 腎機能を悪化させる独立した危険因子であることは広く知られている. |
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| AbstractList | 「I. はじめに」多くの要因が腎移植患者の長期生存に影響を及ぼしているが, 中でもヒト白血球抗原(Human Leukocyte Antigen: HLA)は特に重要である. HLAタイピング技術は進化し, 3次元の構成要素をより正確に決定可能になった. そして, HLA抗体検査の最新技術が普及し, リスク予測も可能になりつつある. しかしながら, 拒絶反応発症原因や移植腎喪失に抗体が関与していることは変わらない. これは, 主要組織適合遺伝子複合体(Major Histocompatibility Complex: MHC)が拒絶反応に深く関与しており, HLAミスマッチ数や種類が細胞性と抗体関連拒絶反応の両方を引き起こすことを示唆している. HLA抗体は, 術前に検出されるドナー特異的HLA抗体(Donor Specific Antibody: DSA)も重要であるが, 移植後に検出されるde novo DSA(dnDSA)も重要とされ, 腎機能を悪化させる独立した危険因子であることは広く知られている. |
| Author | 尾本, 和也 神澤, 太一 海上, 耕平 田邉, 一成 古澤, 美由紀 石田, 英樹 清水, 朋一 |
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| References | 17) Tambur AR, Buckingham M, McDonald L. Development of donor-specific and non-donor-specific HLA-DP antibodies post-transplant: the role of epitope sharing and epitope matching. Clin Transpl 2006; 32: 399-404. 14) Saper MA, Bjorkman PJ, Wiley DC. Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution. J Mol Biol 1991; 219: 277-319. 4) DeVos JM, Gaber AO, Knight RJ, et al. Donor-specific HLA-DQ antibodies may contribute to poor graft outcome after renal transplantation. Kidney Int 2012; 82: 598-604. 12) Liapis H, Gaut JP, Klein C. Banff histopathological consensus criteria for preimplantation kidney biopsies. Am J Transplant 2017; 17: 140-150. 2) Wiebe C, Gibson IW, Blydt-Hansen TD, et al. Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant. Am J Transplant 2012; 12 : 1157-1167. 7) Wiebe C, Pochinco D, Blydt-Hansen TD, et al. Class II HLA epitope matching—a strategy to minimize de novo donor-specific antibody development and improve outcomes: class II epitope matching to minimize de novo DSA. Am J Transplant 2013; 13: 3114-3122. 10) El-Awar N, Jucaud V, Nguyen A. HLA epitopes: the targets of monoclonal and alloantibodies defined. J Immunol Res 2017; 2017: 1-16. 3) Wiebe C, Rush DN, Nevins TE, et al. Class II eplet mismatch modulates tacrolimus trough levels required to prevent donor-specific antibody development. J Am Soc Nephrol 2017; 28: 3353-3362. 23) Wiebe C, Gibson IW, Blydt-Hansen TD, et al. Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant. Am J Transplant 2012; 12: 1157-1167. 5) Willicombe M, Brookes P, Sergeant R, et al. De novo DQ donor-specific antibodies are associated with a significant risk of antibody-mediated rejection and transplant glomerulopathy. Transplantation 2012; 94: 172-177. 11) Ikeda N, Kojima H, Nishikawa M, et al. Determination of HLA-A, -C, -B, -DRB1 allele and haplotype frequency in Japanese population based on family study. Tissue Antigens 2015; 85: 252-259. 6) Ntokou IS, Iniotaki AG, Kontou EN, et al. Long-term follow up for anti-HLA donor specific antibodies postrenal transplantation: high immunogenicity of HLA class II graft molecules. Transpl Int 2011; 24: 1084-1093. 20) Kosmoliaptsis V, Mallon DH, Chen Y. Alloantibody responses after renal transplant failure can be better predicted by donor-recipient HLA amino acid sequence and physicochemical disparities than conventional HLA matching. Am J Transplant 2016; 16: 2139-2147. 18) Cai J, Terasaki PI, Mao Q, et al. Development of nondonor-specific HLA-DR antibodies in allograft recipients is associated with shared epitopes with mismatched donor DR antigens. Am J Transplant 2006; 6: 2947-2954. 13) Bjorkman PJ, Strominger JL, Wiley DC. Crystallization and X-ray diffraction studies on the histocompatibility antigens HLA-A2 and HLA-A28 from human cell membranes. J Mol Biol 1985; 186: 205-210. 1) Opelz G, Döhler B. Effect of human leukocyte antigen compatibility on kidney graft survival: comparative analysis of two decades. Transplantation 2007; 84: 137-143. 8) Duquesnoy RJ. A structurally based approach to determine HLA compatibility at the humoral immune level. Hum Immunol 2006; 67: 847-862. 9) Duquesnoy RJ. Antibody—reactive epitope determination with HLAMatchmaker and its clinical applications. Tissue Antigens 2011; 77: 525-534. 21) Sapir-Pichhadze R, Tinckam K, Quach K. HLA-DR and -DQ eplet mismatches and transplant glomerulopathy: a nested case-control study. Am J Transplant 2015; 15: 137-148. 22) El-Zoghby ZM, Stegall MD, Lager DJ, et al. Identifying specific causes of kidney allograft loss. Am J Transplant 2009; 9: 527-535. 15) Marrari M, Conca R, Praticò-Barbato L, et al. Brief report: why did two patients who type for HLA-B13 have antibodies that react with all Bw4 antigens except HLA-B13? Transpl Immunol 2011; 25: 217-220. 19) Tambur AR, Rosati J, Roitberg S. Epitope analysis of HLA-DQ antigens: what does the antibody see? Transplantation 2014; 98: 157-166. 16) Marrari M, Duquesnoy RJ. Why can sensitization by an HLA-DR2 mismatch lead to antibodies that react also with HLA-DR1? Hum Immunol 2009; 70: 403-409. |
| References_xml | – reference: 1) Opelz G, Döhler B. Effect of human leukocyte antigen compatibility on kidney graft survival: comparative analysis of two decades. Transplantation 2007; 84: 137-143. – reference: 3) Wiebe C, Rush DN, Nevins TE, et al. Class II eplet mismatch modulates tacrolimus trough levels required to prevent donor-specific antibody development. J Am Soc Nephrol 2017; 28: 3353-3362. – reference: 11) Ikeda N, Kojima H, Nishikawa M, et al. Determination of HLA-A, -C, -B, -DRB1 allele and haplotype frequency in Japanese population based on family study. Tissue Antigens 2015; 85: 252-259. – reference: 8) Duquesnoy RJ. A structurally based approach to determine HLA compatibility at the humoral immune level. Hum Immunol 2006; 67: 847-862. – reference: 9) Duquesnoy RJ. Antibody—reactive epitope determination with HLAMatchmaker and its clinical applications. Tissue Antigens 2011; 77: 525-534. – reference: 15) Marrari M, Conca R, Praticò-Barbato L, et al. Brief report: why did two patients who type for HLA-B13 have antibodies that react with all Bw4 antigens except HLA-B13? Transpl Immunol 2011; 25: 217-220. – reference: 4) DeVos JM, Gaber AO, Knight RJ, et al. Donor-specific HLA-DQ antibodies may contribute to poor graft outcome after renal transplantation. Kidney Int 2012; 82: 598-604. – reference: 16) Marrari M, Duquesnoy RJ. Why can sensitization by an HLA-DR2 mismatch lead to antibodies that react also with HLA-DR1? Hum Immunol 2009; 70: 403-409. – reference: 12) Liapis H, Gaut JP, Klein C. Banff histopathological consensus criteria for preimplantation kidney biopsies. Am J Transplant 2017; 17: 140-150. – reference: 13) Bjorkman PJ, Strominger JL, Wiley DC. Crystallization and X-ray diffraction studies on the histocompatibility antigens HLA-A2 and HLA-A28 from human cell membranes. J Mol Biol 1985; 186: 205-210. – reference: 14) Saper MA, Bjorkman PJ, Wiley DC. Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution. J Mol Biol 1991; 219: 277-319. – reference: 17) Tambur AR, Buckingham M, McDonald L. Development of donor-specific and non-donor-specific HLA-DP antibodies post-transplant: the role of epitope sharing and epitope matching. Clin Transpl 2006; 32: 399-404. – reference: 6) Ntokou IS, Iniotaki AG, Kontou EN, et al. Long-term follow up for anti-HLA donor specific antibodies postrenal transplantation: high immunogenicity of HLA class II graft molecules. Transpl Int 2011; 24: 1084-1093. – reference: 10) El-Awar N, Jucaud V, Nguyen A. HLA epitopes: the targets of monoclonal and alloantibodies defined. J Immunol Res 2017; 2017: 1-16. – reference: 20) Kosmoliaptsis V, Mallon DH, Chen Y. Alloantibody responses after renal transplant failure can be better predicted by donor-recipient HLA amino acid sequence and physicochemical disparities than conventional HLA matching. Am J Transplant 2016; 16: 2139-2147. – reference: 18) Cai J, Terasaki PI, Mao Q, et al. Development of nondonor-specific HLA-DR antibodies in allograft recipients is associated with shared epitopes with mismatched donor DR antigens. Am J Transplant 2006; 6: 2947-2954. – reference: 5) Willicombe M, Brookes P, Sergeant R, et al. De novo DQ donor-specific antibodies are associated with a significant risk of antibody-mediated rejection and transplant glomerulopathy. Transplantation 2012; 94: 172-177. – reference: 21) Sapir-Pichhadze R, Tinckam K, Quach K. HLA-DR and -DQ eplet mismatches and transplant glomerulopathy: a nested case-control study. Am J Transplant 2015; 15: 137-148. – reference: 19) Tambur AR, Rosati J, Roitberg S. Epitope analysis of HLA-DQ antigens: what does the antibody see? Transplantation 2014; 98: 157-166. – reference: 2) Wiebe C, Gibson IW, Blydt-Hansen TD, et al. Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant. Am J Transplant 2012; 12 : 1157-1167. – reference: 22) El-Zoghby ZM, Stegall MD, Lager DJ, et al. Identifying specific causes of kidney allograft loss. Am J Transplant 2009; 9: 527-535. – reference: 23) Wiebe C, Gibson IW, Blydt-Hansen TD, et al. Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant. Am J Transplant 2012; 12: 1157-1167. – reference: 7) Wiebe C, Pochinco D, Blydt-Hansen TD, et al. Class II HLA epitope matching—a strategy to minimize de novo donor-specific antibody development and improve outcomes: class II epitope matching to minimize de novo DSA. Am J Transplant 2013; 13: 3114-3122. |
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| Snippet | 「I. はじめに」多くの要因が腎移植患者の長期生存に影響を及ぼしているが, 中でもヒト白血球抗原(Human Leukocyte Antigen: HLA)は特に重要である. HLAタイピング技術は進化し, 3次元の構成要素をより正確に決定可能になった. そして, HLA抗体検査の最新技術が普及し,... |
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| SubjectTerms | chronic antibody mediated rejection dnDSA graft function HLA epitope mismatch kidney transplantation |
| Title | 腎臓移植におけるエピトープミスマッチ解析の意義について |
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