FR209602 and related compounds, novel antifungal lipopeptides from Coleophoma crateriformis no.738 - I. Taxonomy, fermentation, isolation and physico-chemical properties

• Published in: Journal of antibiotics Vol. 59; no. 3; pp. 137 - 144
• Main Authors: Kanasaki, R, Sakamoto, K, Hashimoto, M, Takase, S, Tsurumi, Y, Fujie, A, Hino, M, Hashimoto, S, Hori, Y
• Format: Journal Article
• Language: English
• Published: TOKYO Japan Antibiotics Research Assoc 01.03.2006
• Subjects: Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Biotechnology & Applied Microbiology; Fermentation; Fungi - classification; Fungi - metabolism; Immunology; Life Sciences & Biomedicine; Lipopeptides; Lipoproteins - chemistry; Lipoproteins - isolation & purification; Microbiology; Peptides, Cyclic - chemistry; Peptides, Cyclic - isolation & purification; Pharmacology & Pharmacy; Science & Technology; FR-209604; antifungal; ECHINOCANDIN; FR209603; ACULEACIN; 1,3-beta-glucan synthesis; FR209602; WF11899A; MULUNDOCANDIN
• ISSN: 0021-8820
• DOI: 10.1038/ja.2006.20

Novel antifungal lipopeptides, FR209602, FR209603 and FR209604, were isolated from the fermentation broth of a fungal strain No. 738 which was identified as Coleolphoma crateriformis from morphological and physiological characteristics. The antibiotics were purified by solvent extraction, HP-20, YMC-ODS and silica gel column chromatography and lyophilization. These compounds were Structurally similar to FR901379 previously reported by ourselves which had a sulfate residue in the cyclic peptide portion.