TRPチャネル − アノクタミン1相互作用の生理機能
「はじめに」 体外環境の変化を知覚することは生存において重要であり, 特に侵害性刺激を感じることは時として生命維持に直結する不可欠な生理機能である. 末梢の自由神経終末には化学的および物理的刺激の多くを受容する分子機構があるため, 一次感覚神経は危機的環境の回避にも重要である. 侵害性熱刺激や酸刺激はカプサイシンの受容体であるTRPV1を活性化し, 且つそれらの同時刺激はTRPV1を相乗的に賦活化する. 一方, アノクタミン1(ANO1)は2008年に同定されたカルシウム活性化型陰イオンチャネルであり, 熱感受性を持つことが報告されている. TRPV1は一次感覚神経においてANO1と共局在して...
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| Published in | PAIN RESEARCH Vol. 33; no. 1; pp. 1 - 9 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本疼痛学会
30.03.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0915-8588 2187-4697 |
| DOI | 10.11154/pain.33.1 |
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| Abstract | 「はじめに」 体外環境の変化を知覚することは生存において重要であり, 特に侵害性刺激を感じることは時として生命維持に直結する不可欠な生理機能である. 末梢の自由神経終末には化学的および物理的刺激の多くを受容する分子機構があるため, 一次感覚神経は危機的環境の回避にも重要である. 侵害性熱刺激や酸刺激はカプサイシンの受容体であるTRPV1を活性化し, 且つそれらの同時刺激はTRPV1を相乗的に賦活化する. 一方, アノクタミン1(ANO1)は2008年に同定されたカルシウム活性化型陰イオンチャネルであり, 熱感受性を持つことが報告されている. TRPV1は一次感覚神経においてANO1と共局在しており, これら二つのイオンチャネルの相互作用は神経興奮を増強する分子機構であることを筆者らは明らかにした. 本稿では, TRPV1-ANO1相互作用について, その発見に至った経緯も踏まえて論じたいと思う. |
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| AbstractList | 「はじめに」 体外環境の変化を知覚することは生存において重要であり, 特に侵害性刺激を感じることは時として生命維持に直結する不可欠な生理機能である. 末梢の自由神経終末には化学的および物理的刺激の多くを受容する分子機構があるため, 一次感覚神経は危機的環境の回避にも重要である. 侵害性熱刺激や酸刺激はカプサイシンの受容体であるTRPV1を活性化し, 且つそれらの同時刺激はTRPV1を相乗的に賦活化する. 一方, アノクタミン1(ANO1)は2008年に同定されたカルシウム活性化型陰イオンチャネルであり, 熱感受性を持つことが報告されている. TRPV1は一次感覚神経においてANO1と共局在しており, これら二つのイオンチャネルの相互作用は神経興奮を増強する分子機構であることを筆者らは明らかにした. 本稿では, TRPV1-ANO1相互作用について, その発見に至った経緯も踏まえて論じたいと思う. |
| Author | 柴崎, 貢志 歌, 大介 富永, 真琴 高山, 靖規 古江, 秀昌 |
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| Copyright | 2018 日本疼痛学会 |
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| DOI | 10.11154/pain.33.1 |
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Physiol., 148 (2016) 375- 392. 3) Caputo, A., Caci, E., Ferrera, L., Pedemonte, N.,Barsanti, C., Sondo, E., Pfeffer, U., Ravazzolo, R., Zegarra-Moran, O., Galietta, L. J., TMEM16A, a membrane protein associated with calciumdependent chloride channel activity, Science, 322 (2008) 590-594. 14) Jin, X., Shah, S., Du, X., Zhang, H., Gamper, N.,Activation of Ca(2+) -activated Cl(-) channel ANO1 by localized Ca(2+) signals, J. Physiol.,594 (2016) 19-30. 33) Uta, D., Furue, H., Pickering, A.E., Rashid, M.H.,Mizuguchi-Takase, H., Katafuchi, T., Imoto, K., Yoshimura, M., TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord, Eur. J. Neurosci., 31 (2010) 1960-1973. |
| References_xml | – reference: 1) Benfenati, V., Caprini, M., Dovizio, M., Mylonakou, M.N., Ferroni, S., Ottersen, O.P., Amiry-Moghaddam, M., An aquaporin-4 ⁄ transient receptor potential vanilloid 4 (AQP4⁄TRPV4) complex is essential for cell-volume control in astrocytes, Proc. Natl. Acad. Sci. U.S.A., 108 (2011) 2563-2568. – reference: 28) Takayama, Y., Shibasaki, K., Suzuki, Y., Yamanaka, A., Tominaga, M., Modulation of water efflux through functional interaction between TRPV4 and TMEM16A ⁄ anoctamin 1, FASEB J., 28 (2014) 2238-2248. – reference: 23) Schroeder, B.C., Cheng, T., Jan, Y.N., Jan, L.Y., Expression cloning of TMEM16A as a calcium activated chloride channel subunit, Cell, 134 (2008) 1019-1029. – reference: 34) Xu, Z., Lefevre, G.M., Gavrilova, O., Foster St Claire, M.B., Riddick, G., Felsenfeld, G., Mapping of long-range INS promoter interactions reveals a role for calcium-activated chloride channel ANO1in insulin secretion, Proc. Natl. Acad. Sci. U.S.A., 111 (2014) 16760-16765. – reference: 16) Mandadi, S., Tominaga, T., Numazaki, M., Murayama, N., Saito, N., Armati, P.J., Roufogalis, B.D., Tominaga, M., Increased sensitivity of desensitized TRPV1 by PMA occurs through PKCepsilon-mediated phosphorylation at S800, Pain, 123 (2006) 106-116. – reference: 33) Uta, D., Furue, H., Pickering, A.E., Rashid, M.H.,Mizuguchi-Takase, H., Katafuchi, T., Imoto, K., Yoshimura, M., TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord, Eur. J. Neurosci., 31 (2010) 1960-1973. – reference: 14) Jin, X., Shah, S., Du, X., Zhang, H., Gamper, N.,Activation of Ca(2+) -activated Cl(-) channel ANO1 by localized Ca(2+) signals, J. Physiol.,594 (2016) 19-30. – reference: 31) Tian, Y., Schreiber, R., Kunzelmann, K., Anoctamins are a family of Ca2+-activated Cl channels, J. Cell Sci., 125 (2012) 4991-4998. – reference: 3) Caputo, A., Caci, E., Ferrera, L., Pedemonte, N.,Barsanti, C., Sondo, E., Pfeffer, U., Ravazzolo, R., Zegarra-Moran, O., Galietta, L. J., TMEM16A, a membrane protein associated with calciumdependent chloride channel activity, Science, 322 (2008) 590-594. – reference: 20) Paulino, C., Neldner, Y., Lam, A.K., Kalienkova, V., Brunner, J.D., Schenck, S., Dutzler, R., Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A, Elife, 6 (2017). – reference: 26) Suzuki, J., Fujii, T., Imao, T., Ishihara, K., Kuba, H., Nagata, S., Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members, J. Biol. Chem., 288 (2013) 13305-13316. – reference: 17) Mao, S., Garzon-Muvdi, T., Di Fulvio, M., Chen, Y., Delpire, E., Alvarez, F.J., Alvarez-Leefmans, F.J., Molecular and functional expression of cation-chloride cotransporters in dorsal root ganglion neurons during postnatal maturation, J. Neurophysiol., 108 (2012) 834-852. – reference: 9) Furue, H., Katafuchi, T., Yoshimura, M., Sensory processing and functional reorganiza tion of sensory transmission under pathological conditions in the spinal dorsal horn, Neurosci. Res., 48 (2004) 361-368. – reference: 19) Mulier, M., Vriens, J., Voets, T., TRP channel pores and local calcium signals, Cell Calcium, 66 (2017) 19-24. – reference: 6) Crutzen, R., Virreira, M., Markadieu, N., Shlyonsky, V., Sener, A., Malaisse, W.J., Beauwens, R., Boom, A., Golstein, P.E., Anoctamin 1 (Ano1) is required for glucose-induced membrane potential oscillations and insulin secretion by murine beta-cells, Pflugers Arch., 468 (2016) 573-591. – reference: 12) Iwamoto, N., Higashi, T., Furuse, M., Localization of angulin-1⁄LSR and tricellulin at tricellular contacts of brain and retinal endothelial cells in vivo, Cell Struct. Funct., 39 (2014) 1-8. – reference: 24) Shibasaki, K., Suzuki, M., Mizuno, A., Tominaga, M., Effects of body temperature on neural activity in the hippocampus: regulation of resting membrane potentials by transient receptor potential vanilloid 4, J. Neurosci., 27(2007) 1566-1575. – reference: 32) Tien, J., Lee, H.Y., Minor, D.L., Jr., Jan, Y.N., Jan, L.Y., Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC), Proc. Natl. Acad. Sci. U.S.A., 110 (2013) 6352-6357. – reference: 15) Lim, N.K., Lam, A.K., Dutzler, R., Independent activation of ion conduction pores in the dou ble-barreled calcium-activated chloride channel TMEM16A, J. Gen. Physiol., 148 (2016) 375- 392. – reference: 13) Jiang, T., Yu, K., Hartzell, H.C., Tajkhorshid, E., Lipids and ions traverse the membrane by the same physical pathway in the nhTMEM16 scramblase, Elife, 6 (2017). – reference: 2) Brunner, J.D., Lim, N.K., Schenck, S., Duerst, A.,Dutzler, R., X-ray structure of a calcium-acti vated TMEM16 lipid scramblase, Nature, 516 (2014) 207-212. – reference: 5) Cho, H., Yang, Y.D., Lee, J., Lee, B., Kim, T., Jang, Y., Back, S.K., Na, H.S., Harfe, B.D., Wang, F., Raouf, R., Wood, J.N., Oh, U., The calciumactivated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons, Nat. 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| Snippet | 「はじめに」 体外環境の変化を知覚することは生存において重要であり, 特に侵害性刺激を感じることは時として生命維持に直結する不可欠な生理機能である. 末梢の自由神経終末には化学的および物理的刺激の多くを受容する分子機構があるため, 一次感覚神経は危機的環境の回避にも重要である.... |
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| SubjectTerms | Acute pain Anoctamin 1 Isopropylcyclohexanol TRP channel |
| Title | TRPチャネル − アノクタミン1相互作用の生理機能 |
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